In vitro and in vivo models for monkeypox

被引：21

作者：

Rosa, Rafael Borges ^{[1
,2
]}

de Castro, Emilene Ferreira ^{[2
]}

da Silva, Murilo Vieira ^{[2
]}

Paiva Ferreira, Denise Caroline ^{[2
]}

Gomes Jardim, Ana Carolina ^{[3
]}

Santos, Igor Andrade ^{[3
]}

Marinho, Mikaela dos Santos ^{[3
]}

Ferreira Franca, Flavia Batista ^{[4
]}

Pena, Lindomar Jose ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, FIOCRUZ, Dept Virol & Expt Therapy LAVITE, Aggeu Magalhaes Inst IAM, BR-50740465 Recife, PE, Brazil

[2] Fed Univ Uberlandia REBIR UFU, Rodents Anim Facil Complex, BR-38400902 Uberlandia, MG, Brazil

[3] Univ Fed Uberlandia, Inst Biomed Sci, BR-38405302 Uberlandia, MG, Brazil

[4] Univ Fed Uberlandia, Inst Biomed Sci, BR-38405318 Uberlandia, MG, Brazil

来源：

ISCIENCE | 2023年 / 26卷 / 01期

关键词：

INBRED MOUSE STRAINS; VIRUS-INFECTION; VACCINIA VIRUS; NONHUMAN-PRIMATES; POX DISEASE; ANTIVIRAL TREATMENT; SMALLPOX VACCINE; PROTEIN BINDS; PRAIRIE DOGS; PROTECTION;

D O I：

10.1016/j.isci.2022.105702

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The emergence and rapid spread outside of monkeypox virus (MPXV) to non-endemic areas has led to another global health emergency in the midst of the COVID-19 pandemic. The scientific community has sought to rapidly develop in vitro and in vivo models that could be applied in research with MPXV. In vitro models include two-dimensional (2D) cultures of immortalized cell lines or primary cells and three-dimensional (3D) cultures. In vitro models are considered cost-effective and can be done in highly controlled conditions; however, they do not always resemble physiological conditions. In this way, several in vivo models are being characterized to meet the growing demand for new studies related to MPXV. In this review, we summarize the main MPXV models that have already been developed and discuss how they can contribute to advance the understanding of its pathogenesis, replication, and transmission, as well as identifying antivirals to treat infected patients.

引用

页数：43

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