Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene x environment moderation and mediation

被引：7

作者：

Elkrief, Laurent ^{[1
,2
]}

Lin, Bochao ^{[3
]}

Marchi, Mattia ^{[4
,5
]}

Afzali, Mohammad H. ^{[1
,2
]}

Banaschewski, Tobias ^{[6
]}

Bokde, Arun L. W. ^{[7
,8
]}

Quinlan, Erin Burke ^{[9
]}

Desrivieres, Sylvane ^{[9
]}

Flor, Herta ^{[10
,11
]}

Garavan, Hugh ^{[12
,13
]}

Gowland, Penny ^{[14
]}

Heinz, Andreas ^{[15
]}

Ittermann, Bernd ^{[16
]}

Martinot, Jean-Luc ^{[17
,18
]}

Martinot, Marie-Laure Paillere ^{[19
,20
]}

Nees, Frauke ^{[6
,10
]}

Orfanos, Dimitri Papadopoulos ^{[21
]}

Paus, Tomas ^{[22
]}

Poustka, Luise ^{[23
]}

Hohmann, Sarah ^{[6
]}

Froehner, Juliane H. ^{[24
,25
]}

Smolka, Michael N. ^{[24
,25
]}

Walter, Henrik ^{[15
]}

Whelan, Robert ^{[26
,27
]}

Schumann, Gunter ^{[9
,28
,29
,30
]}

Luykx, Jurjen ^{[4
]}

Boks, Marco P. ^{[4
]}

Conrod, Patricia J. ^{[1
,2
]}

机构：

[1] St Justine Hosp, Res Ctr, Montreal, PQ, Canada

[2] Univ Montreal, Dept Psychiat & Addictol, Montreal, PQ, Canada

[3] Univ Utrecht, Brain Ctr Univ Med Ctr, Dept Translat Neurosci, Utrecht, Netherlands

[4] Brain Ctr Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands

[5] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Via Giuseppe Campi 287, I-41125 Modena, Italy

[6] Heidelberg Univ, Dept Child & Adolescent Psychiat & Psychotherapy, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, D-68159 Mannheim, Germany

[7] Trinity Coll Dublin, Discipline Psychiat, Sch Med, Dublin 2, Ireland

[8] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin 2, Ireland

[9] Kings Coll London, Ctr Populat Neurosci & Precis Med PONS, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England

[10] Heidelberg Univ, Dept Cognit & Clin Neurosci, Cent Inst Mental Hlth, Med Fac Mannheim, Sq J5, Mannheim, Germany

[11] Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany

[12] Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA

[13] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA

[14] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England

[15] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Charite Mitte,Charitepl 1, Berlin, Germany

[16] Phys Tech Bundesanstalt PTB, Abbestr 2-12, Berlin, Germany

[17] Univ Paris Saciay, INSERM, Unit 1000 Neuroimaging & Psychiat, Univ Paris Descartes,Sorbonne Paris Cite, Paris, France

[18] Maison Solenn, Paris, France

[19] Univ Paris Sud, INSERM, Unit 1000 Neuroimaging & Psychiat, Univ Paris Descartes, Paris, France

[20] Sorbonne Univ, Pitie Saipetriere Hosp, AP HP, Dept Child & Adolescent Psychiat, Paris, France

[21] Univ Paris Saciay, NeuroSpin, CEA, F-91191 Gif Sur Yvette, France

[22] Holland Bioorview Kids Rehabil Hosp, Bioorview Res Inst, Toronto, ON, Canada

[23] Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Von Siebold Str 5, D-37075 Gottingen, Germany

[24] Tech Univ Dresden, Dept Psychiat, Dresden, Germany

[25] Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

[26] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland

[27] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

[28] Humboldt Univ, Dept Psychiat & Psychotherapy, PONS Res Grp, Campus Charite Mitte, Berlin, Germany

[29] Leibniz Inst Neurobiol, Magdeburg, Germany

[30] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence IS, Shanghai, Peoples R China

来源：

PSYCHOLOGICAL MEDICINE | 2023年 / 53卷 / 05期

基金：

美国国家卫生研究院; 英国医学研究理事会; 欧盟地平线“2020”; 爱尔兰科学基金会;

关键词：

Polygenic risk score; cannabis; psychotic-like experience; psychosis risk; SUBSTANCE USE; ASSOCIATION; METAANALYSIS; ADOLESCENCE; LIABILITY; SYMPTOMS; PATTERNS; TOBACCO; VARIANT; ONSET;

D O I：

10.1017/S0033291721003378

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background. It has not yet been determined if the commonly reported cannabispsychosis association is limited to individuals with pre-existing genetic risk for psychotic disorders. Methods. We examined whether the relationship between polygenic risk score for schizophrenia (PRS-Sz) and psychotic-like experiences (PLEs), as measured by the Community Assessment of Psychic Experiences-42 (CAPE-42) questionnaire, is mediated or moderated by lifetime cannabis use at 16 years of age in 1740 of the individuals of the European IMAGEN cohort. Secondary analysis examined the relationships between lifetime cannabis use, PRS-Sz and the various sub-scales of the CAPE-42. Sensitivity analyses including covariates, including a PRS for cannabis use, were conducted and results were replicated using data from 1223 individuals in the Dutch Utrecht cannabis cohort. Results. PRS-Sz significantly predicted cannabis use (p = 0.027) and PLE (p = 0.004) in the IMAGEN cohort. In the full model, considering PRS-Sz and covariates, cannabis use was also significantly associated with PLE in IMAGEN (p = 0.007). Results remained consistent in the Utrecht cohort and through sensitivity analyses. Nevertheless, there was no evidence of a mediation or moderation effects. Conclusions. These results suggest that cannabis use remains a risk factor for PLEs, over and above genetic vulnerability for schizophrenia. This research does not support the notion that the cannabis-psychosis link is limited to individuals who are genetically predisposed to psychosis and suggests a need for research focusing on cannabis-related processes in psychosis that cannot be explained by genetic vulnerability.

引用

页码：1759 / 1769

页数：11

共 2 条

[1] CHILDHOOD ADVERSITY AND CANNABIS USE IN THE DEVELOPMENT OF POSITIVE PSYCHOTIC-LIKE EXPERIENCES: MODERATION EFFECTS OF THE COMT GENE
Alemany, Silvia
Arias, Barbara
Fatjo-Vilas, Mar
Aguilera, Mari
Villa, Helena
Moya, Jorge
Ibanez, Manuel I.
Ortet, Generos
Fananas, Lourdes
SCHIZOPHRENIA RESEARCH, 2012, 136 : S91 - S91
[2] Testing Gene x Environment Moderation of Tobacco and Marijuana Use Trajectories in Adolescence and Young Adulthood
Musci, Rashelle J.
Uhl, George
Maher, Brion
Ialongo, Nicholas S.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 2015, 83 (05) : 866 - 874

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