Dual trajectories of antiretroviral therapy adherence and polypharmacy in women with HIV in the United States

被引：1

作者：

Elbur, Abubaker Ibrahim ^{[1
]}

Ghebremichael, Musie ^{[2
]}

Konkle-Parker, Deborah ^{[3
]}

Jones, Deborah L. ^{[4
]}

Collins, Shelby ^{[5
]}

Adimora, Adaora A. ^{[6
]}

Schneider, Michael F. ^{[7
]}

Cohen, Mardge H. ^{[8
]}

Tamraz, Bani ^{[9
]}

Plankey, Michael ^{[10
]}

Wilson, Tracey ^{[11
]}

Adedimeji, Adebola ^{[12
]}

Haberer, Jessica E. ^{[13
]}

Jacobson, Denise L. ^{[14
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA 02114 USA

[2] MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA

[3] Univ Mississippi, Sch Nursing Med & Populat Hlth, Med Ctr, Jackson, MS USA

[4] Univ Miami, Dept Psychiat & Behav Sci, Miller Sch Med, Miami, FL USA

[5] Emory Univ, Div Infect Dis, Sch Med, Atlanta, GA USA

[6] Univ North Carolina Chapel Hill, Dept Med, Chapel Hill, NC USA

[7] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[8] John H Stroger Jr Hosp Cook Cty, Dept Med, Chicago, IL USA

[9] Univ Calif San Francisco, Sch Pharm, San Francisco, CA USA

[10] Georgetown Univ, Dept Med, Div Gen Internal Med, Med Ctr, Washington, DC USA

[11] SUNY Downstate Hlth Sci Univ, Sch Publ Hlth, Brooklyn, NY USA

[12] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA

[13] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA USA

[14] Harvard T H Chan Sch Publ Hlth, Ctr Biostat AIDS Res, Dept Biostat, Boston, MA USA

来源：

AIDS RESEARCH AND THERAPY | 2023年 / 20卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MEDICATION ADHERENCE; INTERAGENCY HIV; COHORT; HIV/AIDS; ALCOHOL; RISK; MEN;

D O I：

10.1186/s12981-023-00520-4

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BackgroundPolypharmacy, using five or more medications, may increase the risk of nonadherence to prescribed treatment. We aimed to identify the interrelationship between trajectories of adherence to antiretroviral therapy (ART) and polypharmacy.MethodsWe included women with HIV (aged >= 18) enrolled in the Women's Interagency HIV Study in the United States from 2014 to 2019. We used group-based trajectory modeling (GBTM) to identify trajectories of adherence to ART and polypharmacy and the dual GBTM to identify the interrelationship between adherence and polypharmacy.ResultsOverall, 1,538 were eligible (median age of 49 years). GBTM analysis revealed five latent trajectories of adherence with 42% of women grouped in the consistently moderate trajectory. GBTM identified four polypharmacy trajectories with 45% categorized in the consistently low group.ConclusionsThe joint model did not reveal any interrelationship between ART adherence and polypharmacy trajectories. Future research should consider examining the interrelationship between both variables using objective measures of adherence.

引用

页数：12

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