Nod-like receptors in inflammatory arthritis

被引:4
|
作者
Madahar, Sahib Singh [1 ,2 ]
Gideon, Alita [1 ]
Abdul-Sater, Ali A. [1 ,3 ]
机构
[1] York Univ, Muscle Hlth Res Ctr, Sch Kinesiol & Hlth Sci, Toronto, ON, Canada
[2] York Univ, Dept Biol, Toronto, ON, Canada
[3] York Univ, 4700 Keele Str,Farquharson Bldg,Room 353, Toronto, ON M3J 1P3, Canada
基金
加拿大健康研究院;
关键词
Nod -like receptors; Rheumatoid arthritis; Psoriatic arthritis; Gout; Ankylosing spondylitis; Pediatric arthritis; SINGLE-NUCLEOTIDE POLYMORPHISM; JUVENILE IDIOPATHIC ARTHRITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PTPN22 R620W POLYMORPHISM; RHEUMATOID-ARTHRITIS; NLRP3; INFLAMMASOME; TYROSINE-PHOSPHATASE; PSORIATIC-ARTHRITIS; SUSCEPTIBILITY; ASSOCIATION;
D O I
10.1016/j.bj.2023.100655
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nod-like receptors (NLRs) are innate immune receptors that play a key role in sensing components from pathogens and from damaged cells or organelles. NLRs form signaling complexes that can lead to activation of transcription factors or effector caspases - by means of inflammasome activation -Inflammatory arthritis (IA) culminating in promoting inflammation. An increasing body of research supports the role of NLRs in driving pathogenesis of IA, a collection of diseases that include rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis, and pediatric arthritis. In this review, we briefly discuss the main drivers of IA diseases and dive into the evidence for - and against - various NLRs in driving these diseases. We also review the studies examining the use of NLR and inflammasome inhibitors as potential therapies for IA.
引用
收藏
页数:8
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