Evaluation of Corneal Nerve Regeneration After Minimally Invasive Corneal Neurotization

被引:1
|
作者
Su, Dai [1 ,2 ]
Zhang, Jiaying [1 ,2 ]
Wu, Yue [1 ,2 ]
Wang, Wenjin [3 ]
Wang, Wei [3 ,4 ]
Shao, Chunyi [1 ,2 ,5 ]
Li, Jin [1 ,2 ,5 ]
机构
[1] Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Ophthalmol, Shanghai, Peoples R China
[2] Shanghai Key Lab Orbital Dis & Ocular Oncol, Dept Ophthalmol, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, Shanghai, Peoples R China
[4] Shanghai Ninth Peoples Hosp, Dept Plast & Reconstruct Surg, 639 Zhi Zao Ju Rd, Shanghai 200011, Peoples R China
[5] Shanghai Ninth Peoples Hosp, Dept Ophthalmol, 639 Zhi Zao Ju Rd, Shanghai 200011, Peoples R China
来源
ASIA-PACIFIC JOURNAL OF OPHTHALMOLOGY | 2023年 / 12卷 / 05期
关键词
corneal neurotization; in vivo confocal microscopy; neurotrophic keratopathy; DIABETIC PERIPHERAL NEUROPATHY; NEUROTROPHIC KERATOPATHY; CONFOCAL MICROSCOPY; CLINICAL-OUTCOMES; DENDRITIC CELL; REINNERVATION; FIBERS; MODEL;
D O I
10.1097/APO.0000000000000626
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To evaluate the corneal nerve regeneration after minimally invasive corneal neurotization (MICN) and to further clarify the recovery patterns of sensory and trophic functions of the corneal nerves.Design: A retrospective cohort study based in the Shanghai Ninth People's Hospital.Methods: Eighteen patients (18 eyes) who underwent MICN for neurotrophic keratopathy due to intracranial surgery was conducted to analyze their follow-up data at 6, 12, 18, and 24 months after surgery.Results: At 12 months postoperatively, the growth of the central and peripheral corneal nerve fiber density (CNFD) was 11.47 +/- 8.56 and 14.73 +/- 8.08 n/mm 2 with subsequent improvement slowing down, and the patient's corneal epithelium defect was healed ahead of the accomplishment of corneal nerve regeneration. The number of dendritic cells also reached its peak. At 18 months postoperatively, the recovery of central and peripheral corneal sensation was 37.22 +/- 23.06 mm and 39.38 +/- 18.08 mm with no subsequent improvement, and the growth of the central and peripheral corneal nerve branch density (CNBD) was 29.69 +/- 11.05 and 43.75 +/- 1.41 n/mm 2 , with a positive and significant correlation between corneal sensation and CNBD (at central r =0.632, P <0.005; at peripheral r =0.645, P <0.005). At 24 months postoperatively, mean CNFD, CNBD, and corneal sensation recovered significantly compared with preoperative, but a few patients' corneal sensation recovered insignificantly with good CNFD recovery and poor CNBD recovery.Conclusions: After MICN, the trophic function of the corneal nerve recovers before the sensory function, and in particular, the recovery of sensation is based on the coexistence of the corneal nerve trunk and branches.
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页码:427 / 436
页数:10
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