The Application of Corynebacterium glutamicum in L-Threonine Biosynthesis

被引：8
|
作者：
Duan, Min [1 ]
Chen, Shuo [1 ]
Liu, Xinli [1 ,2 ]
Liu, Jianhang [1 ,2 ]
Zhu, Deqiang [1 ,2 ]
机构：
[1] Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Peoples R China
[2] Qilu Univ Technol, Shandong Acad Sci, Sch Bioengn, Shandong Prov Key Lab Microbial Engn, Jinan 250353, Peoples R China
来源：
FERMENTATION-BASEL | 2023年 / 9卷 / 09期
关键词：
L-threonine; Corynebacterium glutamicum; metabolic engineering; biosynthesis; AMINO-ACIDS; HOMOSERINE DEHYDROGENASE; ASPARTATE KINASE; INHIBITION; DELETION; FAMILY; FLAVUM; THRE;
D O I：
10.3390/fermentation9090822
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
l-threonine is an essential amino acid in human and animal nutrition. It is widely used in food, medicine, feed, and other fields. The global market scale exceeds 700,000 tons per year. Corynebacterium glutamicum, as a chassis cell for industrial amino acid production, has the advantages of biological safety and strong environmental adaptability, and is a potential strain for the efficient production of l-threonine. This article systematically reviewed the function and application of l-threonine, the pathway of C. glutamicum to synthesize l-threonine, and the use of metabolic engineering technology to improve the production of l-threonine.
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页数：9
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