Fast, instrument-free and low-cost selection of high-affinity aptamers

被引：1
|
作者：
Wang, Yong [1 ]
机构：
[1] Penn State Univ, University Pk, PA 16802 USA
来源：
NATURE BIOTECHNOLOGY | 2024年 / 42卷 / 08期
关键词：
D O I：
10.1038/s41587-023-01980-9
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We designed a method for fast aptamer selection by integrating biomaterials science, engineering principles and biology. Aptamer candidates dynamically interacting with immobilized targets in a three-dimensional, non-fouling and macroporous polyethylene glycol hydrogel were rapidly enriched and selected with high affinity against five protein targets.
引用
收藏
页码：1190 / 1191
页数：2
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