Associations between community-level patterns of prenatal alcohol and tobacco exposure on brain structure in a non-clinical sample of 6-year-old children: a South African pilot study

被引：6
|
作者：
Uban, Kristina. A. A. [1 ,2 ]
Jonker, Deborah [3 ,4 ]
Donald, Kirsten. A. A. [3 ,5 ]
Bodison, Stefanie. C. C. [6 ]
Brooks, Samantha. J. J. [7 ]
Kan, Eric [8 ]
Steigelmann, Babette [1 ]
Roos, Annerine [4 ,5 ]
Marshall, Andrew [8 ]
Adise, Shana [8 ]
Butler-Kruger, Letitia [4 ]
Melly, Brigitte [3 ]
Narr, Katherine. L. L. [9 ,10 ]
Joshi, Shantanu. H. H. [9 ,11 ]
Odendaal, Hein. J. J. [12 ]
Sowell, Elizabeth. R. R. [8 ]
Stein, Dan. J. J. [4 ,5 ,13 ]
机构：
[1] Univ Calif Irvine, Publ Hlth, Irvine, CA USA
[2] Ctr Neurobiol Learning & Memory, Irvine, CA 92697 USA
[3] Univ Cape Town, Dept Paediat & Child Hlth, Cape Town, South Africa
[4] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa
[5] Univ Cape Town, Neurosci Inst, Cape Town, South Africa
[6] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Occupat Therapy, Gainesville, FL USA
[7] Liverpool John Moores Univ, Fac Hlth, Liverpool, Lancashire, England
[8] Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Dept Pediat, Los Angeles, CA USA
[9] Univ Calif Los Angeles, Ahmanson Lovelace Brain Mapping Ctr, Geffen Sch Med, Dept Neurol, Los Angeles, CA USA
[10] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA
[11] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA USA
[12] Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa
[13] South African Med Res Council SAMRC, Unit Risk & Resilience Mental Disorders, Cape Town, South Africa
来源：
ACTA NEUROPSYCHIATRICA | 2024年 / 36卷 / 02期
关键词：
teratogen; prenatal alcohol exposure (PAE); prenatal tobacco exposure (PTE); brain structure; children; low-middle income country (LMIC); SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; SPECTRUM DISORDERS; SEGMENTATION; PREVALENCE; MORPHOLOGY; DRINKING; SYSTEM;
D O I：
10.1017/neu.2022.34
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The current small study utilised prospective data collection of patterns of prenatal alcohol and tobacco exposure (PAE and PTE) to examine associations with structural brain outcomes in 6-year-olds and served as a pilot to determine the value of prospective data describing community-level patterns of PAE and PTE in a non-clinical sample of children. Participants from the Safe Passage Study in pregnancy were approached when their child was similar to 6 years old and completed structural brain magnetic resonance imaging to examine with archived PAE and PTE data (n = 51 children-mother dyads). Linear regression was used to conduct whole-brain structural analyses, with false-discovery rate (FDR) correction, to examine: (a) main effects of PAE, PTE and their interaction; and (b) predictive potential of data that reflect patterns of PAE and PTE (e.g. quantity, frequency and timing (QFT)). Associations between PAE, PTE and their interaction with brain structural measures demonstrated unique profiles of cortical and subcortical alterations that were distinct between PAE only, PTE only and their interactive effects. Analyses examining associations between patterns of PAE and PTE (e.g. QFT) were able to significantly detect brain alterations (that survived FDR correction) in this small non-clinical sample of children. These findings support the hypothesis that considering QFT and co-exposures is important for identifying brain alterations following PAE and/or PTE in a small group of young children. Current results demonstrate that teratogenic outcomes on brain structure differ as a function PAE, PTE or their co-exposures, as well as the pattern (QFT) or exposure.
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页码：87 / 96
页数：10
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