Serendipitous synthesis of 2,3-dihydroquinazolin-4(1H)-ones in ZnCl2/urea deep eutectic solvent

被引：1

作者：

Kumar, Gobind ^{[1
]}

Khubone, Lungisani ^{[1
]}

Seboletswe, Pule ^{[1
]}

Manhas, Neha ^{[3
]}

Makhanya, Talent ^{[3
]}

Bhargava, Gaurav ^{[2
]}

Singh, Parvesh ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, P Bag X54001, ZA-4000 Durban, South Africa

[2] IK Gujral Punjab Tech Univ Kapurthala, Dept Chem Sci, Kapurthala 144603, Punjab, India

[3] Durban Univ Technol, Dept Chem, ML Sultan Campus, ZA-4000 Durban, South Africa

来源：

ARKIVOC | 2023年

基金：

新加坡国家研究基金会;

关键词：

Deep eutectic solvent; 2,3-dihydroquinazolinone; green chemistry; heterocyclic compounds; solvent-free; ORGANIC-SYNTHESIS; ONE-POT; ENANTIOSELECTIVE SYNTHESIS; QUINAZOLINE DERIVATIVES; ENVIRONMENTALLY BENIGN; ISATOIC ANHYDRIDE; ACID; CATALYST; GREEN;

D O I：

10.24820/ark.5550190.p012.167

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A green, sustainable, and efficient one-pot, synthetic strategy for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones (DHQs) was developed. The ZnCl2/urea used as a deep eutectic solvent (DES) not only efficiently promoted the condensation between isatoic anhydride and benzaldehyde but unexpectedly acted as a nitrogen source (like ammonia) in situ to afford DHQs in excellent yields. This approach offers remarkable advantages, involving the triple role of DES in the synthesis of DHQs, atom-economical, green organocatalysts, metal-free conditions, cost-effectiveness, and tolerance to a range of functional groups. [GRAPHICS] .

引用

页数：13

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