Mesoporous silica-encapsulated Co-doped ceria nanodots with enhanced peroxidase-like activity enable intensive and long-lasting chemiluminescence for glutathione detection

被引:9
|
作者
Qian, Shiyu [1 ]
Zhang, Haiyang [1 ]
Sun, Xiaoxiao [1 ]
Tan, Dehong [1 ]
Tian, Fang [1 ]
Zhang, Tianqi [1 ]
Cui, Yu [1 ]
Chen, Xiang [1 ]
Liang, Xiaoye [1 ]
Cai, Zheng [1 ]
Li, Lingling [1 ]
机构
[1] Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211166, Peoples R China
来源
SENSORS AND ACTUATORS B-CHEMICAL | 2023年 / 383卷
基金
中国国家自然科学基金;
关键词
Glow-type chemiluminescence; Ceria nanodots; Nanozyme; Glutathione; Biosensing;
D O I
10.1016/j.snb.2023.133609
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Chemiluminescence (CL) assay has been considered as a sensitive method for quantitative detection of gluta-thione (GSH), a significant regulatory metabolite in cells. However, most reported CL assays present flash-type CL emission with limited detection accuracy and repeatability. Herein, an intensive and long-lasting glow-type CL system was proposed based on a novel bimetallic Co-doped ceria mesoporous nanocomposite (Co-cer-ia@MSN), which was prepared by in-situ growth of sub-3 nm ultrasmall Co-ceria nanodots within the pore channels of mesoporous silica nanospheres (MSN). Attributing to the confinement effect of MSN and the superior peroxidase-like catalytic activity of Co-ceria nanodots, this nanocomposite could function as a nanozyme to catalyze luminol/H2O2 CL reaction, producing a robust and long-lasting CL emission with a long plateau for over 1.2 h at physiological pH. Surprisingly, both the CL intensity and duration time were found to exist a strong dependence on GSH concentration. Accordingly, the proposed glow-type CL platform was further applied for GSH determination with a limit of detection down to 10 nM. This strategy was successfully utilized for quan-titative evaluation of cellular GSH levels, indicating its broad prospects in clinical diagnosis.
引用
收藏
页数:9
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