Assessment of inflammatory cytokines in exhaled breath condensate and exposure to mixtures of organic pollutants in brick workers

Brick production causes a lot of pollution in the form of dust, fumes, and toxic substances. Therefore, brick workers are highly exposed to pollutants and present a high risk of developing respiratory diseases. The objective of this research was to determine the exposure to polycyclic aromatic hydrocarbons (PAHs) and toluene in urine and evaluate the effects on health using markers of oxidative stress in exhaled breath condensate (EBC) as well as the exposure to pollutants in suspended particles of the studied area. Exposure to PAHs and toluene was evaluated using hydroxylated markers (OH) of PAHs and hippuric acid in urine, respectively. Cytokines like TNF-alpha, INF-y, IL-2, IL-4, IL-6, IL-8, IL-10 y GMCSF in EBC were also evaluated. -PM2.5 particles were measured during an 8-h work shift. The results in brick workers presented a total OH-PAHs concentration of 97.3 mu g/ L and hippuric acid concentration of 0.2 g/L. The environmental concentrations of suspended particles were found within a range of 41.67- 3541.6 mu g/m(3). The median of cytokines oscillated between 11.8 pg/mL to 1041 pg/mL. In conclusion, these results are similar to those of occupations in which there is high exposure to pollutants and populations with lung diseases. For that reason, the brick production sector requires prevention and control strategies against the pollutants emitted.