Association of OPRK1 rs963549 and rs997917 polymorphisms with opioid use disorder and the related phenotypes

被引：1
|
作者：
Ozkan-Kotiloglu, Selin [1 ]
Kaya-Akyuzlu, Dilek [2 ]
Yalcin-Sahiner, Safak [3 ,4 ]
Ayaz, Nagihan [5 ]
机构：
[1] Kirsehir Ahi Evran Univ, Fac Sci & Art, Dept Mol Biol & Genet, Kirsehir, Turkiye
[2] Ankara Univ, Inst Forens Sci, TR-06590 Ankara, Turkiye
[3] Ankara Numune Training & Res Hosp, AMATEM Clin, TR-06374 Ankara, Turkiye
[4] Kutahya Hlth Sci Univ, Fac Med, Dept Mental Hlth & Dis, TR-43020 Kutahya, Turkiye
[5] Ankara City Hosp, TR-06800 Ankara, Turkiye
来源：
PHARMACOGENOMICS | 2023年 / 24卷 / 06期
关键词：
individual differences; opioid use disorder; opioid withdrawal; OPRK1; gene; kappa-opioid receptor; MESSENGER-RNA STABILITY; RECEPTOR GENE; OPIATE WITHDRAWAL; ALCOHOL DEPENDENCE; LOCUS-CERULEUS; DOPAMINE; DYNORPHIN; NEURONS; STRESS; SUSCEPTIBILITY;
D O I：
10.2217/pgs-2023-0037
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To evaluate the association between OPRK1 rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes.Methods: A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. OPRK1 rs963549 and rs997917 were analyzed by PCR-RFLP. Craving, opioid withdrawal and the intensity of depressive and anxiety symptoms were measured by the appropriate scales.Results: OPRK1 rs963549 variation showed a trend of association with decreased opioid withdrawal. No significant associations were found between OPRK1 rs963549 and rs997917 polymorphisms and craving, depression or anxiety symptoms. Neither single OPRK1 SNPs nor OPRK1 haplotypes were associated with OUD.Conclusion: Our results could be useful for treatment failures of individuals who experience greater opioid withdrawal due to their OPRK1 rs963549 genotypes.
引用
收藏
页码：325 / 334
页数：10
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