Background and objective: Entropy generation (a novel prospective) in different thermodynamical processes has usefulness in polymer process. Importance of entropy optimization is noticed in nuclear reactions, heat exchangers, biological system, electronic cooling, combustion, porous media, thermal systems, turbo machinery, turbine systems and many others. Entropy minimization has been utilized for assessment of thermal energy through thermodynamical processes. Entropy minimization rate is employed to boosts up efficiency of thermodynamical system. Therefore, present investigation is aimed to investigate optimized radiative flow of micropolar nanofluid due to exponential stretched curved surface. Heat expression with heat generation and radiation is explored. Moreover, interesting aspects of homogenous and heterogeneous chemical reactions are also presented. For nanofluid characteristics the Buongiorno's model is incorporated. Velocity and thermal slip conditions are explored. Mathematical modeling of flow expressions are presented through curvilinear coordinates. Entropy rate is modeled employing second law of thermodynamics.Methodology: Suitable relations have been employed to get the dimensionless systems. Resultant dimensionless systems are computed through ND-solve technique.Results: Graphical analysis for sundry variables on liquid flow, entropy generation, temperature, microrotation velocity and concentration are addressed. An opposite scenario for microrotation and velocity holds against material parameter. Heat transport rate augments in presence of slip constraint. Change in radiation constant and thermophoresis variable correspond to higher temperature. Entropy generation has enhancing trend for radiation parameter. Concentration has opposite scenario for random and thermophoresis diffusion variables. Larger thermal ratio parameter enhances entropy generation.