Multidrug-resistant Neisseria gonorrhoeae isolate SE690: mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial- susceptible genomic lineage, Sweden, September 2022

被引：16

作者：

Golparian, Daniel ^{[1
]}

Vestberg, Nora ^{[2
]}

Sodersten, Wiktor ^{[3
]}

Jacobsson, Susanne ^{[1
]}

Ohnishik, Makoto ^{[4
]}

Fang, Hong ^{[2
]}

Bhattarai, Karin Haij ^{[2
]}

Unemo, Magnus ^{[1
,5
]}

机构：

[1] Orebro Univ, Fac Med & Hlth, WHO Collaborating Ctr Gonorrhoea & Other STIs, Natl Reference Lab STI,Dept Lab Med, Orebro, Sweden

[2] Karolinska Univ Hosp, Dept Clin Microbiol, Huddinge, Sweden

[3] Karolinska Univ Hosp, Dept Venerol, Stockholm, Sweden

[4] Natl Inst Infect Dis, Dept Bacteriol 1, Tokyo, Japan

[5] Univ Coll London UCL, Inst Global Hlth, London, England

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 10期

关键词：

D O I：

10.2807/1560-7917.ES.2023.28.10.2300125

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report a ceftriaxone-resistant, multidrug-resist-ant urogenital Neisseria gonorrhoeae in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone i g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8i30, NG-STAR CCi885 (new NG-STAR ST4859) and mosaic penA-6o.oo1. The latter, causing ceftriax-one resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial -susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftri-axone resistance.

引用

页数：6