Synthesis of cis-fused cyclopentenone-pyrrolidine scaffolds via sequential aza-Piancatelli and Conia-ene type reactions in one pot

被引：3

作者：

Solanke, Pooja R. ^{[1
,2
]}

Kumar, Prakash ^{[1
,2
]}

Mainkar, Prathama S. ^{[1
,2
]}

Nayani, Kiranmai ^{[1
,2
]}

Chandrasekhar, Srivari ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 31期

关键词：

COOPERATIVE CATALYSIS; 5-ENDO-DIG CARBOCYCLIZATION; REARRANGEMENT;

D O I：

10.1039/d4cc00104d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel one-pot protocol that enables sequential execution of an aza-Piancatelli rearrangement and a Conia-ene type reaction has been developed under Lewis acid catalysis. Here, a combination of B(C6F5)(3) and Cu(OTf)(2), triethylamine, and triphenylphosphine yielded a wide range of cis-fused cyclopentenone-pyrrolidine scaffolds in one pot with good yields and diastereoselectivity.

引用

页码：4234 / 4237

页数：4