Changes in Iron Status Biomarkers with Advancing Age According to Sex and Menopause: A Population-Based Study

被引:7
|
作者
Merlo, Francesco [1 ]
Groothof, Dion [2 ]
Khatami, Farnaz [1 ,3 ,4 ]
Ahanchi, Noushin Sadat [1 ,3 ,5 ]
Wehrli, Faina [6 ]
Bakker, Stephan J. L. [2 ]
Eisenga, Michele F. [2 ]
Muka, Taulant [7 ]
机构
[1] Univ Bern, Inst Social & Prevent Med, CH-3012 Bern, Switzerland
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands
[3] Univ Bern, Grad Sch Hlth Sci, CH-3012 Bern, Switzerland
[4] Univ Tehran Med Sci, Community Med Dept, Tehran 1417613151, Iran
[5] Lausanne Univ Hosp, Dept Internal Med, Internal Med, Rue Bugnon 21, CH-1005 Lausanne, Switzerland
[6] Dr Risch, Lagerstr 30, CH-9470 Buchs, Switzerland
[7] Epistudia, Schanzenstr 4a, CH-3008 Bern, Switzerland
基金
瑞士国家科学基金会;
关键词
iron biomarkers; age and menopausal status; DANISH WOMEN; SERUM FERRITIN; STORES; PREVALENCE; DIFFERENCE; DEFICIENCY; HEPCIDIN; DISEASE;
D O I
10.3390/jcm12165338
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The risk of chronic diseases increases markedly with age and after menopause. An increase in bodily iron following menopause could contribute to this phenomenon of increased risk of chronic diseases. We aimed to investigate how various iron biomarkers change with advancing age, according to sex and menopausal status. Methods: We enrolled community-dwelling individuals with available information on ferritin, transferrin, iron, hepcidin, and soluble transferrin receptor levels from the Prevention of Renal and Vascular Endstage Disease study. The association of the iron biomarkers with age, sex, and menopausal status was investigated with linear regression models. Results: Mean (SD) age of the 5222 individuals (2680 women [51.3%], among whom 907 [33.8%] were premenopausal, 529 [19.7%] perimenopausal, and 785 [29.3%] postmenopausal), was 53.4 (12.0) years. Iron biomarkers showed a constant increase in women throughout their life course, in some cases at older ages surpassing values in men who, in turn, showed consistently higher levels of iron status compared to women in most age categories. Ferritin, hepcidin, and transferrin saturation levels were 3.03, 2.92, and 1.08-fold (all p < 0.001) higher in postmenopausal women compared to premenopausal. Conclusions: We found that iron accumulates differently depending on sex, age, and menopausal status. An increased iron status was identified in women, especially during and after menopause.
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页数:13
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