Aerobic C-C Bond Cleavage of Allylic Alcohols via Co-Catalyzed Hydrogen Atom Transfer

被引：5
|
作者：
Deng, Meng [1 ]
Chu, Mengqi [2 ]
Li, Nan [2 ]
Sun, Guohui [1 ]
Li, Fei [1 ]
Guo, Dade [2 ]
Kang, Guohui [2 ]
Ji, Baoming [2 ]
机构：
[1] Luoyang Normal Univ, Coll Food & Drug, Luoyang Key Lab Organ Funct Mol, Luoyang 471934, Henan, Peoples R China
[2] Luoyang Normal Univ, Coll Chem & Chem Engn, Henan Key Lab Funct Oriented Porous Mat, Luoyang 471934, Henan, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 14期
基金：
中国国家自然科学基金;
关键词：
MOLECULAR-OXYGEN; ENANTIOSPECIFIC SYNTHESIS; FRAGMENTATION; ALKENES; OLEFINS; FE;
D O I：
10.1021/acs.orglett.3c00556
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, efficient method has been developed for the Co-III-H-catalyzed aerobic C-C bond cleavage of tertiary allylic alcohols to access ketones. This novel approach presents excellent chemoselectivity, good functional group compatibility, and high yields. This reaction occurs through a HAT-initiated peroxide intermediate, and an adjacent glycol-type diradical fragmentation process is recommended.
引用
收藏
页码：2420 / 2425
页数：6
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