Synthesis of derivatives of 6-aryl-2,2′-bipyridine complexes with PtII as potential antitumor agents

被引：2

作者：

Abramov, V. M. ^{[1
]}

Cheremnykh, L. A. ^{[1
]}

El'tsov, O. S. ^{[1
]}

Tokhtueva, M. D. ^{[1
]}

Melekhin, V. V. ^{[1
,2
]}

Paramonova, A. V. ^{[1
]}

Mezentseva, A. A. ^{[1
]}

Chernysheva, A. E. ^{[1
]}

Makeev, O. G. ^{[2
]}

机构：

[1] Ural Fed Univ, Chem Technol Inst, 28 ul Mira, Ekaterinburg 620002, Russia

[2] Ural State Med Univ, 17 ul Klyuchevskaya, Ekaterinburg 620109, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

Pt-II complexes of aryl- and diaryl-2,2'-bipyridines; Krohnke method; cycloplatination; antitumor activity in vitro; IN-VITRO;

D O I：

10.1007/s11172-023-4094-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New Pt-II complexes of aryl- and diaryl-2,2'-bipyridines were prepared using the Krohnke method for the further synthesis of pyridine derivatives. Signal assignment in the H-1 and C-13 NMR spectra was performed for the 1D and 2D NMR spectral data. The primary screening evaluation of the antitumor activity of the synthesized compounds on cultured human cells in vitro showed high biological significance of selected samples. The cell death under the action of the studied compounds proceeds via apoptosis type as shown by fluorescent dyeing and polymerase chain reaction in the real time.

引用

页码：2848 / 2859

页数：12

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