Ocular microvascular alteration in patients with myocardial infarction-a new OCTA study

被引:6
|
作者
Wu, Jun-Yi [2 ]
Hu, Jin-Yu [1 ,2 ]
Ge, Qian-Min [1 ,2 ]
Xu, San-Hua [1 ,2 ]
Zou, Jie [1 ,2 ]
Kang, Min [1 ,2 ]
Ying, Ping [1 ,2 ]
Wei, Hong [1 ,2 ]
Ling, Qian [1 ,2 ]
He, Liang-Qi [1 ,2 ]
Chen, Cheng [1 ,2 ]
Shao, Yi [1 ,2 ]
机构
[1] Fudan Univ, Eye & ENT Hosp, Dept Ophthalmol, Shanghai 200030, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept Neurosurg, Nanchang 330006, Jiangxi, Peoples R China
关键词
CORONARY-HEART-DISEASE; RETINAL BLOOD-FLOW; FLUORESCEIN ANGIOGRAPHY; ATHEROSCLEROSIS RISK; DIABETIC-RETINOPATHY; COHERENCE; SIGNS;
D O I
10.1038/s41598-023-50283-1
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Myocardial infarction is defined as a sudden decrease or interruption in blood flow to the coronary arteries, causing ischemic necrosis of the corresponding cardiomyocytes. It is unclear whether systemic macrovascular alterations are associated with retinal microvascular changes. This study utilized optical coherence tomography angiography (OCTA) to compare variations in conjunctival vascular density and fundus retinal vessel density between patients with myocardial infarction (MI) and healthy controls. This study recruited 16 patients (32 eyes) with MI and 16 healthy controls (32 eyes). The superficial retinal layer (SRL), deep retinal layer (DRL) and conjunctival capillary plexus in each eye were evaluated by OCTA. Parameters measured included the density of the temporal conjunctival capillary, retinal microvascular (MIR) and macrovascular (MAR) alterations and total MIR (TMI). The microvascular density of each retinal region was evaluated by the hemisphere segmentation (SR, SL, IL, and IR), annular partition (C1, C2, C3, C4, C5 and C6), and modified early treatment of diabetic retinopathy study (R, S, L, and I) methods. In the macular area, the superficial and deep retinal microvascular densities displayed notable variations. In the superficial layers, the superficial TMI, superficial MIR, and superficial MAR, as well as densities in the SL, IL, S, L, C1, C2, C5 and C6 regions, were significantly lower in MI patients (p < 0.05 each). In the deep layers, the deep MIR and deep TMI), as well as densities in the SL, IL, L, C1, C2 and C6 regions were significantly lower in MI patients (p < 0.05 each). In contrast, the conjunctival microvascular density was significantly higher in MI patients than in healthy controls (p < 0.001). The microvascular densities measured in the deep and superficial retinal layers and in the conjunctiva differ in MI patients and healthy controls. OCTA is effective in detecting changes in the ocular microcirculation.
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页数:10
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