Effectiveness of SARS-CoV-2 vaccines on hemodialysis patients in Japan: A nationwide cohort study

被引：14

作者：

Kikuchi, Kan ^{[1
]}

Nangaku, Masaomi ^{[2
]}

Ryuzaki, Munekazu ^{[3
]}

Yamakawa, Tomoyuki ^{[4
]}

Yoshihiro, Ota ^{[5
]}

Hanafusa, Norio ^{[6
]}

Sakai, Ken ^{[7
]}

Kanno, Yoshihiko ^{[8
]}

Ando, Ryoichi ^{[9
]}

Shinoda, Toshio ^{[10
]}

Wakino, Shu ^{[11
]}

Nakamoto, Hidetomo ^{[12
]}

Takemoto, Yoshiaki ^{[13
]}

Akizawa, Tadao ^{[14
]}

机构：

[1] Shimoochiai Clin, Div Nephrol, Tokyo, Japan

[2] Univ Tokyo, Div Nephrol & Endocrinol, Grad Sch Med, Tokyo, Japan

[3] Tokyo Saiseikai Cent Hosp, Dept Nephrol, Tokyo, Japan

[4] Shirasagi Hosp, Kidney Ctr, Tokyo, Japan

[5] Nagoya Mem Hosp, Nagoya, Aichi, Japan

[6] Tokyo Womens Med Univ, Dept Blood Purificat, Tokyo, Japan

[7] Toho Univ, Dept Nephrol, Fac Med, Tokyo, Japan

[8] Tokyo Med Univ, Dept Nephrol, Tokyo, Japan

[9] Seishokai Mem Hosp, Dept Nephrol, Tokyo, Japan

[10] Tsukuba Int Univ, Fac Med & Hlth Sci, Tsukuba, Ibaraki, Japan

[11] Tokushima Univ, Inst Biomed Sci, Dept Nephrol, Grad Sch, Tokushima, Japan

[12] Saitama Med Univ, Dept Gen Internal Med, Saitama, Japan

[13] Osaka City Univ, Grad Sch Med, Dept Urol, Shirasagi Hosp, Osaka, Japan

[14] Showa Univ, Dept Med, Div Nephrol, Sch Med, Tokyo, Japan

来源：

THERAPEUTIC APHERESIS AND DIALYSIS | 2023年 / 27卷 / 01期

关键词：

breakthrough infection; COVID-19; dialysis; SARS-CoV-2; vaccine;

D O I：

10.1111/1744-9987.13887

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction This study compared the outcomes of dialysis patients who received SARS-CoV-2 vaccine with those who did not use data from the Japanese COVID-19 registry. Methods A total of 1260 dialysis patients with confirmed positive SARS-CoV-2 infection was included in this study. Patients were divided into two groups: patients who experienced breakthrough infection and those who were unvaccinated. The need of oxygen supplementation and mortality risks were compared using multivariate logistic regression analysis. Results The mortality rate was 24.2% in unvaccinated patients and 8.6% in breakthrough patients. The odds ratio of need of oxygen supplementation in the breakthrough patients relative to unvaccinated patients was 0.197. The hazard ratio of mortality in the breakthrough patients relative to unvaccinated patients was 0.464. Conclusion Our prospective observational study showed that SRAS-CoV-2 vaccination in hemodialysis patients is vital for reducing need of oxygen supplementation and mortality risk.

引用

页码：19 / 23

页数：5

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