OPTIMAL CONDITIONS FOR PURIFICATION AND DRYING OF DRY EXTRACT FROM THE AERIAL PART OF Hypericum scabrum AND Hypericum perforatum

The factors affecting purification of concentrated extracts obtained from the aerial parts of two Hypericum species (H. scabrum L. and H. perforatum L.) using 80% EtOH were studied. A five-fold treatment with extraction naphtha followed by six-fold extraction with EtOAc was shown to provide a dry extract with a hypericin content of at least 0.29%. The recommended conditions for obtaining a spray-dried extract of Hypericum were coolant temperature at the inlet, 160 - 180 & DEG;C; at the outlet, 80 - 90 & DEG;C; solution delivery rate, 5 L/h; air pressure supplied to the nozzle, 0.15 MPa; and solution concentration, 15%. A unified technology for production of Hypericum dry extract substance from the aerial parts of H. scabrum and H. perforatum was developed and could produce a finished product that met the requirements of foreign pharmacopoeias.