Central nervous system (CNS) tumors in children comprise a highly heterogenous and complex group of diseases. Historically, diagnosis and confirmation of these tumors were routinely based on histological examination. However, recently obtained data demonstrate that such a diagnostic approach is not completely accurate and could lead to misdiagnosis. Also, in recent times, the quantity and quality of molecular diagnostic methods have greatly improved, which influences the current classification methods and treatment approach for pediatric CNS tumors. Nowadays, molecular methods, such as DNA methylation profiling, are an integral part of diagnosing brain and spinal tumors in children. In this paper, we present the case of an infant with a posterior fossa tumor who demonstrated a non-specific morphology and whose diagnosis was verified only after DNA methylation.
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Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA USA
Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
Harvard Med Sch, Dept Pediat, Boston, MA 02115 USAChildrens Healthcare Atlanta, Dept Pediat Hematol & Oncol, Atlanta, GA 30329 USA
机构:
Univ Cincinnati, Cincinnati, OH USA
Cincinnati Childrens Hosp Med Ctr, Div Oncol, Canc & Blood Dis Inst, Cincinnati, OH 45229 USAUniv Cincinnati, Cincinnati, OH USA
de Blank, Peter
Bandopadhayay, Pratiti
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Dana Farber Boston Childrens Canc & Blood Disorde, Dept Pediat, Boston, MA USA
Harvard Med Sch, Boston, MA 02115 USA
Broad Inst MIT & Harvard, Boston, MA USAUniv Cincinnati, Cincinnati, OH USA
Bandopadhayay, Pratiti
Haas-Kogan, Daphne
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Harvard Med Sch, Boston, MA 02115 USA
Boston Childrens Hosp, Dept Radiat Oncol, Dana Farber Canc Inst, Brigham & Womens Hosp, Boston, MA USAUniv Cincinnati, Cincinnati, OH USA
Haas-Kogan, Daphne
Fouladi, Maryam
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Univ Cincinnati, Cincinnati, OH USA
Cincinnati Childrens Hosp Med Ctr, Div Oncol, Canc & Blood Dis Inst, Cincinnati, OH 45229 USAUniv Cincinnati, Cincinnati, OH USA
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Univ San Buenaventura Cali, Fac Human & Social Sci, Psychol Program, Cali, ColombiaUniv San Buenaventura Cali, Fac Human & Social Sci, Psychol Program, Cali, Colombia
Gomez, Manuel Jose Guerrero
Urrego, Angela Jimenez
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Univ San Buenaventura Cali, Fac Human & Social Sci, Psychol Program, Cali, ColombiaUniv San Buenaventura Cali, Fac Human & Social Sci, Psychol Program, Cali, Colombia
Urrego, Angela Jimenez
Gonzales, Fernando
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Clin Occidente, Cali 760001, ColombiaUniv San Buenaventura Cali, Fac Human & Social Sci, Psychol Program, Cali, Colombia
Gonzales, Fernando
Carvajal, Alejandro Botero
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Univ Santiago de Cali, Fac Hlth, Psychol Program, Cali 760001, ColombiaUniv San Buenaventura Cali, Fac Human & Social Sci, Psychol Program, Cali, Colombia
机构:
St Jude Childrens Res Hosp, Dept Global Pediat Med, 262 Danny Thomas Pl, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Global Pediat Med, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Moreira, Daniel C.
Bouffet, Eric
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St Jude Childrens Res Hosp, Dept Global Pediat Med, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Hosp Sick Children, Div Haematol Oncol, Toronto, ON, CanadaSt Jude Childrens Res Hosp, Dept Global Pediat Med, 262 Danny Thomas Pl, Memphis, TN 38105 USA
Bouffet, Eric
Qaddoumi, Ibrahim
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St Jude Childrens Res Hosp, Dept Global Pediat Med, 262 Danny Thomas Pl, Memphis, TN 38105 USA
St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Global Pediat Med, 262 Danny Thomas Pl, Memphis, TN 38105 USA
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Royal Manchester Childrens Hosp, Dept Haematol Oncol, Manchester M13 9WL, Lancs, EnglandRoyal Manchester Childrens Hosp, Dept Haematol Oncol, Manchester M13 9WL, Lancs, England
Kilday, John-Paul
Bartels, Ute Katharina
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Univ Toronto, Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, CanadaRoyal Manchester Childrens Hosp, Dept Haematol Oncol, Manchester M13 9WL, Lancs, England