The role of pyroptosis-related lncRNA risk signature in ovarian cancer prognosis and immune system

被引:2
|
作者
Wu, Yanling [1 ]
Liang, Lei [1 ]
Li, Qin [2 ]
Shu, Lilu [2 ]
Wang, Peter [2 ]
Huang, Shufeng [1 ]
机构
[1] Shenzhen Qianhai Shekou Free Trade Zone Hosp, Dept Gynecol, Shenzhen 518067, Guangdong, Peoples R China
[2] Zhejiang Zhongwei Med Res Ctr, Dept Res & Dev, Hangzhou 310018, Zhejiang, Peoples R China
关键词
LncRNA; Ovarian cancer; Target; Pyroptosis; Immune system; CELL-DEATH;
D O I
10.1007/s12672-023-00767-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Ovarian cancer is a leading cause of death in females with gynecologic cancers. Pyroptosis is a relatively new discovered programmed cell death that is believed to be associated with inflammation. However, studies on pyroptosis-related lncRNAs in ovarian cancer are limited. In this study, we identified 29 pyroptosis-related genes and screened out 72 pyroptosis-related lncRNAs. Furthermore, the 72 lncRNAs were eliminated to 2 survival-related lncRNAs using Cox regression and Lasso regression to build an ovarian cancer prognostic prediction signature and were further validated on the test set. We adopted a riskscore from the two-gene signature, and the survival in low-risk group was higher than the high-risk group. Functional enrichment analysis indicated that the differentially expressed genes (DEGs) between two risk groups were associated with tumor immunity. This study implies that pyroptosis-related genes are closely related to tumor immunity and could be potential therapeutic factors for ovarian cancer treatment.
引用
收藏
页数:14
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