The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics

被引：14
|
作者：
Zhang, Sijia [1 ,2 ]
Zong, Yan [1 ,2 ]
Chen, Leichong [1 ,2 ]
Li, Qianwen [1 ,2 ]
Li, Zhenyu [1 ,2 ]
Meng, Rui [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Inst Radiat Oncol, Tongji Med Coll, Wuhan 430022, Peoples R China
来源：
DISCOVER ONCOLOGY | 2023年 / 14卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Disulfiram (DSF); Tumors; Therapeutic drugs; Immune regulation; Programmed cell death-ligand 1 (PD-L1); TARGETING BIOMIMETIC DELIVERY; ALDEHYDE DEHYDROGENASE ALDH; IMMUNOGENIC CELL-DEATH; KAPPA-B ACTIVITY; DRUG DISULFIRAM; TUMOR-IMMUNITY; COPPER; INHIBITION; DIETHYLDITHIOCARBAMATE; LINES;
D O I：
10.1007/s12672-023-00729-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
More than 60 years ago, disulfiram (DSF) was employed for the management of alcohol addiction. This promising cancer therapeutic agent inhibits proliferation, migration, and invasion of malignant tumor cells. Furthermore, divalent copper ions can enhance the antitumor effects of DSF. Molecular structure, pharmacokinetics, signaling pathways, mechanisms of action and current clinical results of DSF are summarized here. Additionally, our attention is directed towards the immunomodulatory properties of DSF and we explore novel administration methods that may address the limitations associated with antitumor treatments based on DSF. Despite the promising potential of these various delivery methods for utilizing DSF as an effective anticancer agent, further investigation is essential in order to extensively evaluate the safety and efficacy of these delivery systems.
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页数：18
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