Cu-Catalyzed Polychloromethylamination of Styrenes through C(sp3)-H Bond Cleavage

被引：0
|
作者：
Zhu, Fengxiang [1 ]
Xue, Jianxin [1 ]
Yin, Pengpeng [1 ]
机构：
[1] Shanxi Univ, Sch Chem & Chem Engn, 92 Wucheng Rd S, Taiyuan 030006, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2023年 / 29卷 / 17期
基金：
中国国家自然科学基金;
关键词：
copper catalyst; multicomponent reaction; polychloromethylamination; radical; styrenes; 3-COMPONENT CARBOAMINATION; ALKENES; AMINO; DIFUNCTIONALIZATION; ALKYNES; ACCESS;
D O I：
10.1002/chem.202203079
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-catalyzed three-component coupling reaction has been developed allowing the rapid building of valuable complex highly functionalized beta-polychloromethyl amines from simple styrenes, arylamines, and dichloromethane/chloroform. Using aryldiazonium salts as a radical initiator, a series of corresponding products are obtained with moderate to good yields under a carbon dioxide or nitrogen atmosphere (50 psi). In addition, good functional group tolerance can be observed.
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页数：5
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