Palladium-Catalyzed Weak-Chelation-Assisted C4-Nitration of Indoles with tert-Butyl Nitrite: Formal Access to Aminated Indoles

被引：6
|
作者：
Banerjee, Sonbidya [1 ]
Punniyamurthy, Tharmalingam [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 05期
关键词：
FUNCTIONALIZATIONS; C4-AMIDATION; ALLYLATION; NITRATION; OXIDATION; ARENES;
D O I：
10.1021/acs.orglett.3c03921
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed weak-chelation-assisted C4-selective nitration of indoles has been accomplished employing tert-butyl nitrite in the presence of oxone under molecular oxygen at a moderate temperature. Aerobic conditions, C4-selectivity, substrate scope, conversion to valuable aminated indoles, and late-stage natural product modifications are the important practical features.
引用
收藏
页码：988 / 993
页数：6
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