Decarboxylative C-N Coupling of 2,2-Difluorobicyclo[1.1.1]pentane (BCP-F2) Building Blocks

被引：2
|
作者：
Ma, Xiaoshen [1 ]
Chen, Joanna L. [1 ]
Gaskins, Bryce E. [1 ]
机构：
[1] Merck & Co Inc, Dept Discovery Chem, 33 Ave Louis Pasteur, Boston, MA 02115 USA
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 09期
关键词：
FLUORINE; POTENT;
D O I：
10.1021/acs.orglett.4c00307
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Described herein is our effort toward achieving the decarboxylative functionalization of 2,2-difluorobicyclo[1.1.1]pentane (BCP-F-2) building blocks. When compared with the nonfluorinated bicyclo[1.1.1]pentane (BCP) analogues, we discovered divergent reactivities. This is the first successful decarboxylative coupling of BCP-F-2 building blocks reported via the photoredox mechanism.
引用
收藏
页码：1947 / 1951
页数：5
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