Impact of microbial genome completeness on metagenomic functional inference

被引：19
|
作者：
Eisenhofer, Raphael [1 ]
Odriozola, Inaki [1 ]
Alberdi, Antton [1 ]
机构：
[1] Univ Copenhagen, Globe Inst, Ctr Evolutionary Hologen, Copenhagen, Denmark
来源：
ISME COMMUNICATIONS | 2023年 / 3卷 / 01期
基金：
欧盟地平线“2020”; 新加坡国家研究基金会;
关键词：
D O I：
10.1038/s43705-023-00221-z
中图分类号：
Q14 [生态学（生物生态学）];
学科分类号：
071012 ; 0713 ;
摘要：
Inferring the functional capabilities of bacteria from metagenome-assembled genomes (MAGs) is becoming a central process in microbiology. Here we show that the completeness of genomes has a significant impact on the recovered functional signal, spanning all domains of metabolic functions. We identify factors that affect this relationship between genome completeness and function fullness, and provide baseline knowledge to guide efforts to correct for this overlooked bias in metagenomic functional inference.
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页数：5
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