Enhanced inactivation increases the sensitivity of pathogenic Cav1.3 L-type Ca2+channel variants to dihydropyridine Ca2+channel blockers

被引：0
|
作者：
Toeroek, F. [1 ,2 ]
Ortner, N. J. [1 ,2 ]
Striessnig, J. [1 ,2 ]
机构：
[1] Univ Innsbruck, Dept Pharmacol & Toxicol, Inst Pharm, Innsbruck, Austria
[2] Ctr Mol Biosci Innsbruck, Innsbruck, Austria
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2023年 / 396卷
基金：
奥地利科学基金会;
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
66
引用
收藏
页码：S18 / S18
页数：1
相关论文
共 50 条
  • [1] Inactivation induced by pathogenic Cav1.3 L-type Ca2+-channel variants enhances sensitivity for dihydropyridine Ca2+ channel blockers
    Torok, Ferenc
    Salamon, Sarah
    Ortner, Nadine J.
    Fernandez-Quintero, Monica L.
    Matthes, Jan
    Striessnig, Jorg
    BRITISH JOURNAL OF PHARMACOLOGY, 2025, 182 (01) : 181 - 197
  • [2] Cav1.3 L-type Ca2+ channel modulates pancreatic β-cell electrical activity and survival
    Theiner, Tamara
    Jacobo-Piqueras, Noelia
    Ortner, Nadine J.
    Geisler, Stefanie
    Tuluc, Petronel
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 98 - 98
  • [3] L-type Ca2+ channel, Cav1.3 in SAN is responsible for the diastolic depolarization of pacemaker potential
    Izumi-Nakaseko, Hiroko
    Ito, Masanori
    Maruyama, Hiroko
    Sugiyama, Atsushi
    Adachi-Akahane, Satomi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011, 115 : 113P - 113P
  • [4] CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current
    Toyoda, Futoshi
    Mesirca, Pietro
    Dubel, Stefan
    Ding, Wei-Guang
    Striessnig, Joerg
    Mangoni, Matteo E.
    Matsuura, Hiroshi
    SCIENTIFIC REPORTS, 2017, 7
  • [5] CaV1.3 L-type Ca2+ channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na+ current
    Futoshi Toyoda
    Pietro Mesirca
    Stefan Dubel
    Wei-Guang Ding
    Joerg Striessnig
    Matteo E. Mangoni
    Hiroshi Matsuura
    Scientific Reports, 7
  • [6] Reduction of TRPC channel-mediated Ca2+influx by Ca2+channel blockers for migraine prevention
    Nakamura, Akiko
    Ishii, Masakazu
    Shimizu, Shunichi
    Hagiwara, Tamio
    Miyazaki, Akira
    Mori, Yasuo
    Kiuchi, Yuji
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103 : 131P - 131P
  • [7] Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3
    Park, So-Jung
    Min, Se-Hong
    Kang, Ho-Won
    Lee, Jung-Ha
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2015, 1848 (10): : 2092 - 2100
  • [8] Slow voltage-dependent inactivation of the L-type Ca2+ channel Cav1.3.
    Izumi-Nakaseko, Hiroko
    Tsuru, Hiromichi
    Adachi-Akahane, Satomi
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103 : 118P - 118P
  • [9] Mechanisms underlying cardiac L-type Ca2+channel dysfunction and expression in diabetic mouse heart
    Fabisch, C.
    Zhang, Y.
    Stindt, D.
    Wiesner, R.
    Bruening, J.
    Matthes, J.
    Herzig, S.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2008, 377 : 55 - 55
  • [10] AKT Regulates Cardiomyocyte Homeostasis by Regulating the Expression of the Voltage-Dependent L-Type Ca2+Channel (Cav1.2)
    Tsushima, Kensuke
    Lopez-Izquierdo, Angelica
    Spitzer, Kenneth W.
    Birnbaum, Morris J.
    Kim, Jaetaek
    Abel, E. Dale
    CIRCULATION, 2013, 128 (22)
12345