The effects of mean platelet volume and red cell distribution width on prognosis in patients with myelodysplastic syndrome

Objective: In this study, the relationship between changes in mean platelet volume (MPV) and erythrocyte distribution width (RDW) with hematological response and survival in patients with myelodysplastic syndrome was investigated.Patients and Methods: Between 1 January 2011 and 31 December 2018, patient characteristics and hemogram results were evaluated during the treatment process among 158 patients diagnosed with myelodysplastic syndrome.Results: The mean age of the patients who were included in the study was 71.53 +/- 12.6 years. The MPV percentage change in the 2-year follow-up of the patients with and without hematological response was significant, at 0.022 +/- 0.11 (2.2%) in those who responded and at 0.069 +/- 0.15 (6.9%) in those who did not (p=0.049). Throughout the same period, the degree of RDW changes in the patients who died was 13.23 +/- 22.97, the degree in those who survived was 2.86 +/- 21.42, and the difference between the two groups was statistically significant (p=0.006).Conclusion: In patients diagnosed with myelodysplastic syndrome, MPV and RDW values can be considered inexpensive and simple laboratory markers that can be used in follow-ups and promising tests to predict both treatment response and survival in the early period and change treatment modalities.