PD1-negative CD45RA effector-memory CD8 T-cells are essential for response to checkpoint inhibition in advanced hepatocellular carcinoma

被引：0

作者：

Cappuyns, Sarah ^{[1
,2
,3
,4
]}

Philips, Gino ^{[3
,4
]}

Vandecaveye, Vincent ^{[5
,6
]}

Boeckx, Bram ^{[3
,4
]}

Schepers, Rogier ^{[3
,4
]}

Van Brussel, Thomas ^{[3
,4
]}

Arijs, Ingrid ^{[3
,4
]}

Mechels, Aurelie ^{[3
,4
]}

Bassez, Ayse ^{[3
,4
]}

Lodi, Francesca ^{[3
,4
]}

Jaekers, Joris ^{[7
]}

Topal, Halit ^{[7
]}

Topal, Baki ^{[7
]}

Bricard, Orian ^{[3
,4
]}

Qian, Junbin ^{[8
,9
]}

Van Cutsem, Eric ^{[1
,2
]}

Verslype, Chris ^{[1
,2
]}

Lambrechts, Diether ^{[3
,4
]}

Dekervel, Jeroen ^{[1
,2
]}

机构：

[1] Univ Hosp Leuven, Dept Gastroenterol, Digest Oncol, Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Oncol, Lab Clin Digest Oncol, Leuven, Belgium

[3] Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium

[4] Vlaams Inst Biotechnol, Ctr Canc Biol, Leuven, Belgium

[5] Univ Hosp Leuven, Dept Radiol, Leuven, Belgium

[6] Katholieke Univ Leuven, Dept Imaging & Pathol, Lab Translat MRI, Leuven, Belgium

[7] Univ Hosp Leuven, Dept Abdominal Surg, Hepatobiliary & Pancreas Surg, Leuven, Belgium

[8] Zhejiang Univ, Womens Hosp, Zhejiang Prov Key Lab Precis Diag & Therapy Major, Sch Med, Hangzhou, Peoples R China

[9] Zhejiang Univ, Inst Genet, Sch Med, Hangzhou, Peoples R China

来源：

JOURNAL OF HEPATOLOGY | 2023年 / 78卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

TOP-066

引用

页码：S524 / S525

页数：2

共 50 条

[1] PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma
Sarah Cappuyns
Gino Philips
Vincent Vandecaveye
Bram Boeckx
Rogier Schepers
Thomas Van Brussel
Ingrid Arijs
Aurelie Mechels
Ayse Bassez
Francesca Lodi
Joris Jaekers
Halit Topal
Baki Topal
Orian Bricard
Junbin Qian
Eric Van Cutsem
Chris Verslype
Diether Lambrechts
Jeroen Dekervel
Nature Communications, 14
[2] PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma
Cappuyns, Sarah
Philips, Gino
Vandecaveye, Vincent
Boeckx, Bram
Schepers, Rogier
Van Brussel, Thomas
Arijs, Ingrid
Mechels, Aurelie
Bassez, Ayse
Lodi, Francesca
Jaekers, Joris
Topal, Halit
Topal, Baki
Bricard, Orian
Qian, Junbin
Van Cutsem, Eric
Verslype, Chris
Lambrechts, Diether
Dekervel, Jeroen
NATURE COMMUNICATIONS, 2023, 14 (01)
[3] Pathologic CD8+Effector Memory T Cells Re-expressing CD45RA in Severe Asthma
Ramonell, R. P.
Oriss, T. B.
Kale, S. L.
McCreary-Partyka, J. C.
Dalton, K. L.
Gauthier, M.
Wenzel, S. E.
Ray, A.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 207
[4] IMMATURE CD45RA(LOW)RO(LOW) T-CELLS IN THE HUMAN CORD-BLOOD .1. ANTECEDENTS OF CD45RA(+) UNPRIMED T-CELLS
BOFILL, M
AKBAR, AN
SALMON, M
ROBINSON, M
BURFORD, G
JANOSSY, G
JOURNAL OF IMMUNOLOGY, 1994, 152 (12): : 5613 - 5623
[5] Tumor Antigen-specific T-cells are Present in the CD8αα+ T-cell Effector-memory Pool
Magalhaes, Isabelle
Vudattu, Nalini Kumar
Jaeger, Elke
Maeurer, Markus J.
JOURNAL OF IMMUNOTHERAPY, 2008, 31 (09) : 840 - 848
[6] EXPRESSION IN-VIVO OF CD45RA, CD45RB AND CD44 ON T-CELL RECEPTOR-TRANSGENIC CD8(+) T-CELLS FOLLOWING IMMUNIZATION
PIHLGREN, M
LIGHTSTONE, L
MAMALAKI, C
RIMON, G
KIOUSSIS, D
MARVEL, J
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (06) : 1755 - 1759
[7] N-Acetylcysteine Blocks the Mechanistic Target of Rapamycin in Pro-Inflammatory Effector-Memory CD4 and CD8 T Cells Re-Expressing CD45RA in Patients with Active Systemic Lupus Erythematosus
Park, Joy
Ji, Lanlan
Cabezas, Jorge
Wang, Xiaojing
Blaker, Bryan
Rao, Dilip
Godavarthy, Aparna
Blaker, Lucero
Ruchi, Fnu
Coman, Ioana
Olsen, Nancy
Lewis, Joshua
Ishimori, Mariko
Kirou, Kyriakos
Donath, Christina
Kahlown, Sara
Sereda, Damira
Furment, Marlene Marte
Nasr, Sandy
Lokineni, Sravani
Ramsey-Goldman, Rosalind
Weisman, Michael
Weinstein, Arthur
Aranow, Cynthia
Katalin, Banki
McDermott, Michael
Wallace, Daniel
Perl, Andras
ARTHRITIS & RHEUMATOLOGY, 2024, 76 : 5427 - 5429
[8] HIGH IL-4 PRODUCTION IS A STABLE PHENOTYPE OF CD8(NEG)CD45RA(NEG)CD27(NEG) T-CELLS
SUNDERPLASSMANN, R
MAJDIC, O
KNAPP, W
HOLTER, W
CELLULAR IMMUNOLOGY, 1995, 160 (02) : 309 - 313
[9] Generation of exhaustion resistant memory CD8 T-cells by simultaneous downmodulation of mTORC1 and PD-1 in activated CD8 T-cells
Berezhnoy, Alexey
Levey, Agata
Rajagopalan, Anugraha
Puplampu-Dove, Yvonne
Gilboa, Eli
CANCER RESEARCH, 2015, 75
[10] ADHESION MOLECULE EXPRESSION ON EFFECTOR AND MEMORY CD8 T-CELLS INVIVO
MOBLEY, JL
RIGBY, SM
DAILEY, MO
FASEB JOURNAL, 1992, 6 (04): : A1415 - A1415

← 1 2 3 4 5 →