Effects of lidocaine, gabapentin, and dexmedetomidine on hemodynamic response during laryngoscopy and intubation

Aim: In this study, we aimed to compare the preventive effects of lidocaine, gabapentin and dexmedetomidine on hemodynamic response secondary to laryngoscopy and intubation.Material and Methods: One hundred twenty ASA I-II patients, aged between 18-50 years who underwent elective tympanomastoidectomy under general anesthesia were enrolled in the study. Patients were randomly divided into 4 groups, each containing 30 patients. Groups 1, 3, and 4 were given placebo tablets orally 1 hour before the operation, Group 2 was given 1600 mg of gabapentin. Ten minutes before the operation, 1.5 mg/kg of 2 % lidocaine was applied to Group 1, 10 ml iv physiological serum was applied to Group 2, 1 mg/kg dexmedetomidine was applied to Group 3 and 10 ml iv physiological serum was applied to Group 4.Results: Heart rates were significantly lower in Group 3 during induction, 3, 5. minutes after induction and in Group 2, 3, 5. minutes after induction when compared to other groups (p<0.05). OAP values in Groups 1 and 4 at 3 minutes after induction were significantly higher than basal values at 3 minutes (p<0.05).Discussion: Dexmedetomidine and gabapentin applied before induction were found to be successful in the suppression of hemodynamic response secondary to intubation and in providing a stabilized hemodynamic status.