Health and Disease: Akkermansia muciniphila, the Shining Star of the Gut Flora

Akkermansia muciniphila (A. muciniphila) has drawn much attention as an important gut strain in recent years. A. muciniphila can influence the occurrence and development of diseases endocrine, nervous, digestive, musculoskeletal, and respiratory systems and other diseases. It improve immunotherapy for some cancers. A. muciniphila is expected to become a new probiotic addition to Lactobacillus and Bifidobacterium. An increase in A. muciniphila abundance through or indirect A. muciniphila supplementation may inhibit or even reverse disease progression. some contrary findings are found in type 2 diabetes mellitus and neurodegenerative diseases, increased A. muciniphila abundance may aggravate the diseases. To enable a more comprehensive understanding of the role of A. muciniphila in diseases, we summarize the relevant information A. muciniphila in different systemic diseases and introduce regulators of A. muciniphila abundance to promote the clinical transformation of A. muciniphila research.