Preliminary study on the effect of ozone exposure on blood glucose level in rats

BACKGROUND: In recent years, people have paid more and more attention to the health hazards caused by O-3 exposure, which will become a major problem after fine particulate matter (PM). OBJECTIVE: To investigate the effects of ozone (O-3) exposure on blood glucose levels in rats under different concentrations and times. METHODS: Eighty rats were divided into control group and three ozone concentration groups. Each group was continuously exposed for 1d, 3d and, 6d, and exposed for 6 hours daily. After exposure, GTT, FBG, and random blood glucose were measured. RESULTS: The FBG value increased significantly on the 6th day of 0.5 ppm and the 3rd and 6th days of 1.0 ppm exposure compared with the control group (P < 0.05). The random blood glucose value was significantly increased on the 3rd and 6th days of each exposure concentration ( P < 0.05). When exposed to 1 ppm concentration, the 120 min GTT value of 1 d, 3 d and, 6 d was significantly higher than that of the control group (P < 0.05). CONCLUSION: After acute O-3 exposure, the blood glucose level of rats was affected by the exposure concentration and time. The concentration of 0.1 ppm had no significant impact on FBG and random blood glucose, and O 3 with a concentration of 0.1 ppm and 0.5 ppm had no significant impact on values of GTT at 90 min, and 120 min.