Hydroxychloroquine dose: balancing toxicity and SLE flare risk

被引：13
|
作者：
Lenfant, Tiphaine [1 ,2 ]
Costedoat-Chalumeau, Nathalie [1 ,2 ]
机构：
[1] Cochin Hosp, AP HP, Dept Internal Med, Ctr Reference Malad Autoimmunes & Syst Rares Fran, Paris, France
[2] Univ Paris Cite CRESS, Ctr Epidemiol & Stat, INSERM, U1153, Paris, France
来源：
NATURE REVIEWS RHEUMATOLOGY | 2023年 / 19卷 / 01期
关键词：
RETINOPATHY;
D O I：
10.1038/s41584-022-00868-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Contemporary guidelines for the management of systemic lupus erythematosus (SLE) recommend prescribing hydroxychloroquine dosages of 5 mg/kg per day or lower to minimize toxicity. However, new evidence raises serious concerns about the risk of SLE flare associated with such doses. How do the benefits and risks of this controversial recommendation balance out?
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页码：6 / 7
页数：2
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