Concurrent pulmonary Aspergillus and non-Aspergillus mold infections in allogeneic hematopoetic cell transplant recipients

被引:1
|
作者
Gali, Varshini [1 ]
Kaltsas, Anna [1 ,2 ]
Cintron, Melvili [3 ]
Papanicolaou, Genovefa A. [1 ,2 ]
Lee, Yeon Joo [1 ,2 ]
机构
[1] Weill Cornell Med Coll, New York, NY USA
[2] Mem Sloan Kettering Canc Ctr, Dept Med, Infect Dis Serv, New York, NY USA
[3] Mem Sloan Kettering Canc Ctr, Lab Med, New York, NY 10065 USA
基金
美国国家卫生研究院;
关键词
Invasive mold infections; Hematopoietic cell transplantation; Concurrent infections; FUNGAL-INFECTIONS; MUCOR INFECTION; EPIDEMIOLOGY;
D O I
10.1016/j.trim.2022.101745
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Patients with hematologic malignancies and recipients of hematopoietic cell transplantation (HCT) are at high risk for invasive mold infections (IMIs). However, risk factors and clinical manifestations are similar between Aspergillus spp. and non-Aspergillus spp. IMIs. Herein, we describe three HCT recipients who had probable invasive pulmonary Aspergillus and non-Aspergillus co-infections. Antifungal agents were changed to voriconazole in two cases where, ultimately, non-Aspergillus molds were diagnosed after these patients died. Our cases highlight the need for better fungal diagnostics in immunocompromised patients. Clinicians should be aware that Aspergillus spp. and non-Aspergillus spp. IMIs can occur concurrently.
引用
收藏
页数:5
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