Polysomnographic evaluation of obstructive sleep apnea treatment with fixed pressure CPAP determined by formula

Purpose The use of continuous positive airway pressure (CPAP) is one of the therapeutic modalities for obstructive sleep apnea (OSA). Manual titration polysomnography and the 90th or 95th percentiles of pressure titrated by automatic CPAP (APAP) are the current standard for determining fixed pressure. Pressures programmed at an arbitrary fixed value, or at preset values based on body mass index (BMI) or by predictive formulas, are presented as alternative forms. This study aimed to evaluate the residual apnea-hypopnea index (r-AHI) in polysomnography with CPAP therapy using pressure determined by formula and assess its feasibility to start treatment. Methods Patients referred for CPAP therapy were followed up in three outpatient assessments and underwent polysomnography study with pressure CPAP obtained by formula. Results The study sample consisted of 80 patients, 41 women; age 58.6 +/- 11.3 years, BMI 34.1 +/- 7.5 kg/m(2) and cervical circumference 42.0 +/- 4.2 cm. Most patients (74%) had severe OSA and Epworth sleepiness scale (ESS) of 12.0 +/- 5.7 points. The calculated average pressure was 7.8 +/- 2.1 cmH(2)O. Polysomnography studies showed an r-AHI of 6.1 +/- 5.2 events/h and reduction of 84% from baseline AHI. The r-AHI in the REM-supine was 8.4 +/- 9.9 events/h. At 30- and 120-day follow-up assessment, adherence to CPAP was 78% and 75% and the ESS score was 6.9 and 6.1 points, respectively. Conclusion Results suggest that a formula provides an effective initial pressure in the majority of patients (73%). This simplified approach appears to be a viable alternative, with reductions in waiting lists and time from diagnosis to initiation of therapy.