COVID-19 outcomes in patients with multiple sclerosis: Understanding changes from 2020 to 2022

被引：2

作者：

Jeantin, Lina ^{[1
]}

Januel, Edouard ^{[2
]}

Labauge, Pierre ^{[3
,4
,5
]}

Maillart, Elisabeth ^{[1
]}

de Seze, Jerome ^{[6
,7
]}

Zephir, Helene ^{[8
]}

Pelletier, Jean ^{[9
]}

Kerschen, Philippe ^{[10
]}

Biotti, Damien ^{[11
,12
,13
]}

Heinzlef, Olivier ^{[14
,20
,21
]}

Guilloton, Laurent ^{[15
]}

Bensa, Caroline ^{[16
]}

Theaudin, Marie ^{[17
,18
]}

Vukusic, Sandra ^{[19
]}

Casez, Olivier

Maurousset, Aude ^{[22
,23
]}

Laplaud, David ^{[24
,25
]}

Berger, Eric ^{[26
,33
]}

Lebrun-Frenay, Christine ^{[27
]}

Bourre, Bertrand ^{[28
]}

Branger, Pierre ^{[29
]}

Stankoff, Bruno ^{[30
]}

Clavelou, Pierre ^{[31
]}

Thouvenot, Eric ^{[32
,34
]}

Manchon, Eric

Moreau, Thibault

Sellal, Francois ^{[35
,36
]}

Zedet, Mickael ^{[37
]}

Papeix, Caroline ^{[16
]}

Louapre, Celine ^{[1
]}

机构：

[1] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Paris Brain Inst ICM,CIC Neurosci,Inserm,CNRS,FCRI, F-75013 Paris, France

[2] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Dept Sante Publ,INSERM,Inst Pierre Louis Epidemiol, Paris, France

[3] Montpellier Univ Hosp, CRC SEP, Dept Neurol, Montpellier, France

[4] Univ Montpellier, INSERM, Inst Neurosci Montpellier INM, Montpellier, France

[5] Univ Montpellier, Montpellier, France

[6] CHU Strasbourg, CIC1434, INSERM 1434, Dept Neurol, Strasbourg, France

[7] CHU Strasbourg, Clin Invest Ctr, CIC1434, INSERM 1434, Strasbourg, France

[8] Univ Lille, CHU Lille, Dept Neurol, INSERM U1172, Lille, France

[9] Aix Marseille Univ, Hop Timone, AP HM, Pole Neurosci Clin Serv Neurol, Marseille, France

[10] Luxembourg Hosp Ctr, Dept Neurol, Luxembourg, Luxembourg

[11] Ctr Ressources & Competences Sclerose Plaques CRC, Clermont Ferrand, France

[12] CHU Toulouse Purpan, Hop Pierre Paul Riquet, Serv Neurol B4, Toulouse, France

[13] Univ Toulouse 3, Inst Toulousain Malad Infectieuses & Inflammatoire, INSERM UMR1291, CNRS UMR5051, Toulouse, France

[14] Ctr Hosp Intercommunal Poissy St Germain En Laye, CRC SEP, Dept Neurol, Poissy, France

[15] Assoc Neurologues Liberaux Langue Francaise, Rambouillet, France

[16] Hop Fdn Adolphe de Rothschild, Dept Neurol, Paris, France

[17] Lausanne Univ Hosp, Dept Clin Neurosci, Lausanne, Switzerland

[18] Univ Lausanne, Lausanne, Switzerland

[19] Hop Neurol & Neurochirurg P Wertheimer, Hosp Civils Lyon, Serv Neurol Sclerose Plaques Pathol Myeline & Neur, Bron, France

[20] CHU Grenoble Alpes, Neurol Pathol Inflammatoires Syst Nerveux, Grenoble, France

[21] Univ Grenoble Alpes, TIMC IMAG, Translat Res Autoimmun & Inflammat Grp T RAIG, Grenoble, France

[22] CHU Tours, Hop Bretonneau, CRC SEP, Tours, France

[23] CHU Tours, Hop Bretonneau, Dept Neurol, Tours, France

[24] CHU Nantes, Serv Neurol, CR2TI UMR1064, Nantes, France

[25] CHU Nantes, CIC0004 INSERM, Nantes, France

[26] CHU Besancon, Serv Neurol, Besancon, France

[27] Univ Nice Cote Azur, CHU Nice Pasteur2, CRCSEP Cote Azur, UR2CA URRIS, Nice, France

[28] Dept Neurol, CHU Rouen, Rouen, France

[29] CHU Caen Normandie, Serv Neurol, Caen, France

[30] Sorbonne Univ, St Antoine Hosp, AP HP, CRCSEP Dept Neurol, Paris, France

[31] CHU Clermont Ferrand, Inserm, Neurodol, CRCSEP,Dept Neurol, Clermont Ferrand, France

[32] Nimes Univ Hosp, Dept Neurol, F-30029 Nimes 9, France

[33] Univ Montpellier, Genomique Fonct, UMR5203, INSERM 1191, Montpellier, France

[34] CHU Dijon, Dept Neurol, EA4184, Dijon, France

[35] Hop Civils Colmar, Dept Neurol, Colmar, France

[36] Univ Strasbourg, Fac Med, Unite INSERM U 1118, Strasbourg, France

[37] Univ Paris Est Creteil, Henri Mondor Univ Hosp, AP HP, Dept Neurol, Creteil, France

来源：

MULTIPLE SCLEROSIS JOURNAL | 2024年 / 30卷 / 03期

关键词：

Multiple sclerosis; SARS-CoV-2; vaccination; COVID-19; vaccines; testing;

D O I：

10.1177/13524585231218149

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

<bold>Background: </bold>Epidemiologic studies on coronavirus disease 2019 (COVID-19) in patients with multiple sclerosis (pwMS) have focused on the first waves of the pandemic until early 2021.<bold>Objectives: </bold>We aimed to extend these data from the onset of the pandemic to the global coverage by vaccination in summer 2022.<bold>Methods: </bold>This retrospective, multicenter observational study analyzed COVISEP registry data on reported COVID-19 cases in pwMS between January 2020 and July 2022. Severe COVID-19 was defined as hospitalization or higher severity.<bold>Results: </bold>Among 2584 pwMS with confirmed/highly suspected COVID-19, severe infection rates declined from 14.6% preomicron wave to 5.7% during omicron wave (p < 0.001). Multivariate analysis identified age (odds ratio (OR) = 1.43, 95% confidence interval (CI) = [1.25-1.64] per 10 years), male sex (OR = 2.01, 95% CI = [1.51-2.67]), obesity (OR = 2.36, 95% CI = [1.52-3.68]), cardiac comorbidities (OR = 2.36, 95% CI = [1.46-3.83]), higher Expanded Disability Status Scale (EDSS) scores (OR = 2.09, 95% CI = [1.43-3.06] for EDSS 3-5.5 and OR = 4.53, 95% CI = [3.04-6.75] for EDSS >= 6), and anti-CD20 therapies (OR = 2.67, 95% CI = [1.85-3.87]) as risk factors for COVID-19 severity. Vaccinated individuals experienced less severe COVID-19, whether on (risk ratio (RR) = 0.64, 95% CI = [0.60-0.69]) or off (RR = 0.32, 95% CI = [0.30-0.33]) anti-CD20.<bold>Discussion: </bold>In pwMS, consistent risk factors were anti-CD20 therapies and neurological disability, emerging as vital drivers of COVID-19 severity regardless of wave, period, or vaccination status.

引用

页码：381 / 395

页数：15

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