Peri Cruiser CAR-T: An innovative platform to reduce on-target off-tumor toxicity of CAR-T therapy

被引：0
|
作者：
Zhang, Shuangshuang [1 ]
Hao, Ruidong [1 ]
Wang, Hongye [1 ]
Yi, Qiao Yong [1 ]
Li Yantao [1 ]
Zhong, Yunpeng [1 ]
Sun, Minmin [1 ]
机构：
[1] Suzhou Immunofoco Biotechnol Co Ltd, Shanghai, Peoples R China
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2023年 / 41卷 / 16期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2539
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Mitigating on-target off-tumor cytotoxicity of EpCAM CAR-T by affinity tuning
    Yang, Huan
    Puc, Janusz
    Yang, Yanping
    McCloskey, Jaclyn E.
    Vedvyas, Yogindra
    Li, Hongtao
    Min, Irene M.
    Jin, Moonsoo M.
    Hofe, Eric, V
    CANCER RESEARCH, 2020, 80 (16)
  • [2] A Mathematical Model for On-Target Off-Tumor Effect of CAR-T Cells on Gliomas
    Santurio, Daniela Silva
    Barros, Luciana Rodrigues Carvalho
    FRONTIERS IN SYSTEMS BIOLOGY, 2022, 2
  • [3] Single-Cell Analysis of Target Antigens of CAR-T Reveals a Potential Landscape of "On-Target, Off-Tumor Toxicity"
    Zhang, Yinyin
    Li, Yingmei
    Cao, Weijie
    Wang, Fang
    Xie, Xinsheng
    Li, Yadan
    Wang, Xiaoyi
    Guo, Rong
    Jiang, Zhongxing
    Guo, Rongqun
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [4] Discovery of inhibitory CAR target DSG1 for damping NECTIN4 on-target off-tumor toxicity in iPSC-derived CAR-T cell therapy
    Hall, Matthew S.
    Dower, Christopher M.
    Miller, Michael
    Wheeler, John
    Carton, Jill
    Manor, Ohad
    Levitsky, Hyam
    CANCER RESEARCH, 2024, 84 (06)
  • [5] A rational mouse model to detect on-target, off-tumor CAR T cell toxicity
    Castellarin, Mauro
    Sands, Caroline
    Da, Tong
    Scholler, John
    Graham, Kathleen
    Buza, Elizabeth
    Fraietta, Joseph A.
    Zhao, Yangbing
    June, Carl H.
    JCI INSIGHT, 2020, 5 (14)
  • [6] TAG72 CAR-T cells decreased tumor progression in colorectal cancer xenograft mouse model without on-target off-tumor toxicity
    Kim, J. -I.
    Chae, J. -A.
    Kim, T. -Y.
    Park, M. -Y.
    Kwon, E.
    Jeong, J. -G.
    Kang, H. -J.
    Kang, B. -C.
    TOXICOLOGY LETTERS, 2022, 368 : S266 - S266
  • [7] Innovative CAR-T Cell Therapy for Solid Tumor; Current Duel between CAR-T Spear and Tumor Shield
    Jo, Yuna
    Ali, Laraib Amir
    Shim, Ju A.
    Ha Lee, Byung
    Hong, Changwan
    CANCERS, 2020, 12 (08) : 1 - 21
  • [8] A novel approach to limit off-tumor toxicity of CAR-T cells targeting solid cancers
    Bartlett, Alex
    Mcwhorter, Matthew
    Collier, Camille
    Jenkins, Chelsea
    Eil, Robert
    CANCER RESEARCH, 2024, 84 (07)
  • [9] Phosphatidylserine as a tumor target for CAR-T cell therapy
    Martin-Otal, Celia
    Sanchez-Moreno, Ines
    Gomez-Moron, Alvaro
    Castro, Carla
    Casares, Noelia
    Navarro, Flor
    Gorraiz, Marta
    Justicia-Lirio, Pedro
    Pareja, Felix
    Collantes, Maria
    Penuelas, Ivan
    Inarrairaegui, Mercedes
    Sangro, Bruno
    Vivas, Isabel
    Larrayoz, Marta
    Rodriguez, Juan Roberto
    Prosper, Felipe
    Hervas-Stubbs, Sandra
    Martin-Cofreces, Noa
    Lasarte, Juan Jose
    Lozano, Teresa
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2025, 13 (02)
  • [10] Target selection for CAR-T therapy
    Wei, Jianshu
    Han, Xiao
    Bo, Jian
    Han, Weidong
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2019, 12 (1)
12345