Computational Fluid Dynamic Analysis of customised 3D-printed bone scaffolds with different architectures

Through the recent years, tissue engineering has been proven as a solid substitute of autografts in the stimulation of bone tissue regeneration, through the development of three dimensional (3D) porous matrices, commonly known as scaffolds. In this work, we analysed two scaffold structures with 500 mu m pore size, by performing computational fluid dynamics simulations, to compare permeability, Wall Shear Stress (WSS), velocity and pressure distributions. Taking into account those parameters the geometry named as "PCL-50" was the best to anticipate showing a superior performance in supporting cell growth due to the improved flow characteristics in the scaffold.