Macrophage polarization in bone implant repair: A review

Macrophages (MO) are highly adaptable and functionally polarized cells that play a crucial role in various physiological and pathological processes. Typically, MO differentiate into two distinct subsets: the proinflammatory (M1) and anti-inflammatory (M2) phenotypes. Due to their potent immunomodulatory and antiinflammatory properties, MO have garnered significant attention in recent decades. In the context of bone implant repair, the immunomodulatory function of MO is of paramount importance. Depending on their polarization phenotype, MO can exert varying effects on osteogenesis, angiogenesis, and the inflammatory response around the implant. This paper provides an overview of the immunomodulatory and inflammatory effects of MO polarization in the repair of bone implants.