Dual functions of the SARS-CoV-2 nucleocapsid domains mediate RNA binding and phase separation

被引:0
|
作者
Estelle, Aidan B. [1 ]
Yu, Zhen [1 ]
Allen, Patrick [2 ]
Barbar, Elisar J. [2 ]
机构
[1] Oregon State Univ, Corvallis, OR USA
[2] Oregon State Univ, Biochem & Biophys, Corvallis, OR USA
关键词
D O I
暂无
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
1050-Pos
引用
收藏
页码:215A / 215A
页数:1
相关论文
共 50 条
  • [1] Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid
    Iserman, Christiane
    Roden, Christine A.
    Boerneke, Mark A.
    Sealfon, Rachel S. G.
    McLaughlin, Grace A.
    Jungreis, Irwin
    Fritch, Ethan J.
    Hou, Yixuan J.
    Ekena, Joanne
    Weidmann, Chase A.
    Theesfeld, Chandra L.
    Kellis, Manolis
    Troyanskaya, Olga G.
    Baric, Ralph S.
    Sheahan, Timothy P.
    Weeks, Kevin M.
    Gladfelter, Amy S.
    MOLECULAR CELL, 2020, 80 (06) : 1078 - +
  • [2] Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA
    Hui Chen
    Yang Cui
    Xuling Han
    Wei Hu
    Min Sun
    Yong Zhang
    Pei-Hui Wang
    Guangtao Song
    Wei Chen
    Jizhong Lou
    Cell Research, 2020, 30 : 1143 - 1145
  • [3] Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA
    Chen, Hui
    Cui, Yang
    Han, Xuling
    Hu, Wei
    Sun, Min
    Zhang, Yong
    Wang, Pei-Hui
    Song, Guangtao
    Chen, Wei
    Lou, Jizhong
    CELL RESEARCH, 2020, 30 (12) : 1143 - 1145
  • [4] RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid
    Estelle, Aidan B.
    Forsythe, Heather M.
    Yu, Zhen
    Hughes, Kaitlyn
    Lasher, Brittany
    Allen, Patrick
    Reardon, Patrick N.
    Hendrix, David A.
    Barbar, Elisar J.
    PNAS NEXUS, 2023, 2 (10):
  • [5] Chemokines simultaneously bind SARS-CoV-2 nucleocapsid protein RNA-binding and dimerization domains
    Lopez-Munoz, Alberto Domingo
    Yewdell, Jonathan W.
    VIROLOGY JOURNAL, 2025, 22 (01)
  • [6] Buffer choice and pH strongly influence phase separation of SARS-CoV-2 nucleocapsid with RNA
    Kathe, Nina C.
    Novakovic, Mihajlo
    Allain, Frederic H. -T.
    MOLECULAR BIOLOGY OF THE CELL, 2024, 35 (05)
  • [7] Structural dynamics of SARS-CoV-2 nucleocapsid protein induced by RNA binding
    Ribeiro-Filho, Helder Veras
    Jara, Gabriel Ernesto
    Batista, Fernanda Aparecida Heleno
    Schleder, Gabriel Ravanhani
    Tonoli, Celisa Caldana Costa
    Soprano, Adriana Santos
    Guimaraes, Samuel Leite
    Borges, Antonio Carlos
    Cassago, Alexandre
    Bajgelman, Marcio Chaim
    Marques, Rafael Elias
    Trivella, Daniela Barretto Barbosa
    Franchini, Kleber Gomes
    Figueira, Ana Carolina Migliorini
    Benedetti, Celso Eduardo
    Lopes-de-Oliveira, Paulo Sergio
    PLOS COMPUTATIONAL BIOLOGY, 2022, 18 (05)
  • [8] Phase separation underlies interactions of the SARS-CoV-2 nucleocapsid protein with nucleoli
    Dogra, Priyanka
    Shirnekhi, Hazheen
    Ferrolino, Mylene C.
    Tolbert, Michele
    Park, Cheon-Gil
    Kriwacki, Richard W.
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 205A - 205A
  • [9] Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
    Cascarina, Sean M.
    Ross, Eric D.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 298 (03)
  • [10] The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
    Cubuk, Jasmine
    Alston, Jhullian J.
    Incicco, J. Jeremias
    Singh, Sukrit
    Stuchell-Brereton, Melissa D.
    Ward, Michael D.
    Zimmerman, Maxwell I.
    Vithani, Neha
    Griffith, Daniel
    Wagoner, Jason A.
    Bowman, Gregory R.
    Hall, Kathleen B.
    Soranno, Andrea
    Holehouse, Alex S.
    NATURE COMMUNICATIONS, 2021, 12 (01)