Efficacy and cost of double filtration plasmapheresis in severe hypertriglyceridemia-induced pancreatitis: A retrospective observational study

被引:3
|
作者
Xu, Xin [1 ]
Gao, Chenyang [1 ]
Han, Pan [1 ,2 ]
机构
[1] Zhejiang Univ, Dept Gen ICU, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Gen Intens Care Unit, 1511 Jianghong Rd, Hangzhou, Zhejiang, Peoples R China
关键词
acute hypertriglyceridemia-induced pancreatitis; clinical results; costs; double filtration plasmapheresis; APHERESIS;
D O I
10.1002/jca.22032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The value of double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced pancreatitis (sHTGP) is controversial. This study aimed to investigate the efficacy of DFPP on clinical outcomes in patients with sHTGP and the costs associated with the procedure. Methods: Patients who underwent DFPP after admission between January 2016 and December 2021 were recruited. Data on lipid profile, clinical parameters, and costs were retrospectively collected and analyzed. Results: Fifty sHTGP patients who received DFPP were enrolled. All of the lipid profile were significantly reduced and maintained a downward trend. The APACHE II score on admission was higher and the reduction after DFPP was more obvious (P < 0.05) in patients with higher triglyceride (TG) levels (>= 33.9 mmol/L) than in patients with lower TG levels. More material fees were expended in the higher TG group due to more DFPP sessions (P < 0.05), but no significant differences existed in total hospital costs between the two groups. Conclusion: DFPP could rapidly and effectively reduce TGs to a safe level. APACHE II score reduction was obvious in patients with TGs >= 33.9 mmol/L and was associated with lipid profile changes. DFPP may benefit sHTGP patients with a TG level higher than the current initiation threshold.
引用
收藏
页码:368 / 375
页数:8
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