Agonist Activation of Orphan Receptor GPR52 Opposes Dopamine D2 Receptor Signaling and Neuromodulation in the Nucleus Accumbens

被引:0
|
作者
Allen, John [1 ]
Murphy, Ryan [1 ]
Dvorak, Nolan M. [1 ]
Laezza, Fernanda [1 ]
机构
[1] Univ Texas Med Branch, Galveston, TX 77555 USA
关键词
Orphan Receptors; Schizophrenia; Dopamine; Anti-psychotics; cAMP Signalling; Nucleus Accumbens Core; Dopamine D2 Receptors;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
P561
引用
收藏
页码:390 / 391
页数:2
相关论文
共 50 条
  • [1] Orphan Receptor GPR52 Profoundly Modulates Dopamine D2 Receptor Signaling: Discovery of GPR52 Druglike Agonists With Antipsychotic Activity
    Allen, John
    Felsing, Daniel
    Murphy, Ryan
    Wang, Pingyuan
    Cunningham, Kathryn
    Zhou, Jia
    NEUROPSYCHOPHARMACOLOGY, 2021, 46 (SUPPL 1) : 376 - 376
  • [2] Bi-directional cAMP signaling crosstalk between dopamine D2 receptors and the constitutively active orphan receptor GPR52
    Murphy, Ryan
    Felsing, Dan
    Allen, John
    FASEB JOURNAL, 2021, 35
  • [3] Dopamine D2 receptor activation in the nucleus accumbens regulates motivation
    Soares-Cunha, C.
    Coimbra, B.
    Borges, S.
    Carvalho, M. M.
    Sousa, N.
    Rodrigues, A. J.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2015, 25 : S54 - S55
  • [4] Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation
    Soares-Cunha, Carina
    Coimbra, Barbara
    David-Pereira, Ana
    Borges, Sonia
    Pinto, Luisa
    Costa, Patricio
    Sousa, Nuno
    Rodrigues, Ana J.
    NATURE COMMUNICATIONS, 2016, 7
  • [5] Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation
    Carina Soares-Cunha
    Barbara Coimbra
    Ana David-Pereira
    Sonia Borges
    Luisa Pinto
    Patricio Costa
    Nuno Sousa
    Ana J. Rodrigues
    Nature Communications, 7
  • [6] The modulation of reward-responses is dependent on dopamine D2 receptor activation in the nucleus accumbens
    Soares-Cunha, C.
    Coimbra, B.
    Borges, S.
    Rodrigues, A. J.
    Sousa, N.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2015, 25 : S200 - S200
  • [7] κ-Opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine
    Thompson, AC
    Zapata, A
    Justice, JB
    Vaughan, RA
    Sharpe, LG
    Shippenberg, TS
    JOURNAL OF NEUROSCIENCE, 2000, 20 (24): : 9333 - 9340
  • [8] The dopamine D1 receptor agonist, but not the D2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens
    Yamada, Hidetaka
    Kuroki, Toshihide
    Nakahara, Tatsuo
    Hashimoto, Kijiro
    Tsutsumi, Tetsuyuki
    Hirano, Makoto
    Maeda, Hisao
    BRAIN RESEARCH, 2007, 1131 (01) : 88 - 96
  • [9] Synergistic activation of the nitrergic system of the nucleus accumbens by dopamine D1 and D2 receptor agonists
    Saul'Skaya N.B.
    Terekhova E.A.
    Neuroscience and Behavioral Physiology, 2014, 44 (4) : 371 - 375
  • [10] Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation
    Trifilieff, P.
    Feng, B.
    Urizar, E.
    Winiger, V.
    Ward, R. D.
    Taylor, K. M.
    Martinez, D.
    Moore, H.
    Balsam, P. D.
    Simpson, E. H.
    Javitch, J. A.
    MOLECULAR PSYCHIATRY, 2013, 18 (09) : 1025 - 1033