A rare finding of double Barr bodies and X-monosomy/X-trisomy mosaicism in a dog with presumed idiopathic epilepsy

被引：0

作者：

Noto, Nicholas T. ^{[1
,4
]}

Raudsepp, Terje ^{[2
]}

Kolb, Ellie ^{[2
]}

Hague, Devon W. ^{[1
]}

Lara, Melissa M. ^{[3
]}

Rosser, Michael F. ^{[1
]}

机构：

[1] Univ Illinois, Dept Vet Clin Med, Coll Vet Med, Urbana, IL USA

[2] Texas A&M Univ, Sch Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX USA

[3] Univ Illinois, Vet Diagnost Lab, Coll Vet Med, Urbana, IL USA

[4] Univ Illinois, Coll Vet Med, Dept Vet Clin Med, 1008 Hazelwood Dr, Urbana, IL 61802 USA

来源：

VETERINARY CLINICAL PATHOLOGY | 2023年

关键词：

blood; canine; cytogenetics; karyotype; neutrophil; GENE-ACTION; CHROMOSOME;

D O I：

10.1111/vcp.13261

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A 4-year-old spayed female Border Collie dog presented to the Neurology and Neurosurgery service for an approximately five-month history of seizures. A complete neurodiagnostic workup was performed and did not reveal any significant abnormalities. The patient's seizures were well controlled with a combination of anticonvulsants. During a manual blood smear review at a follow-up appointment, double Barr bodies were identified in segmented neutrophils. Karyotyping revealed that the patient is mosaic for X-monosomy and X-trisomy, a finding that has never been reported in a dog and is rarely reported in people. This case demonstrates how the identification of abnormal neutrophil nuclear appendages may correlate with chromosomal abnormalities in dogs.

引用

页码：583 / 587

页数：5