Palladium(0)-catalyzed aryne annulation: a powerful strategy for the synthesis of thio-bridged compounds

被引：3
|
作者：
Morja, Mayur, I [1 ]
Chikhalia, Kishor H. [2 ]
机构：
[1] Govt Sci Coll, Dept Chem, Surat 394350, Gujarat, India
[2] Veer Narmad South Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India
来源：
MOLECULAR DIVERSITY | 2023年 / 27卷 / 01期
关键词：
Thio-bridged compounds; Kobayashi precursor; Pd(0) catalyst; Aryne insertion; PALLADIUM-CATALYZED ANNULATION; TRIFLATE;
D O I：
10.1007/s11030-022-10424-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A method for the construction of various thio-bridged compounds is developed using readily available o-(trimethylsilyl)aryl triflates as a source of aryne precursor, catalyzed by simple Pd(dba)(2)/dppe complex. This operationally simple and modular protocol allows thio-bridged compound via C(sp(2) )-C(sp(2)) and C(sp(2))-C(sp(3)) bond formation in promising yields with a broad substrate scope. The key part is in situ generation of an aryne from o-(trimethylsilyl)aryl triflates and their subsequent intermolecular annulation. [GRAPHICS] .
引用
收藏
页码：299 / 311
页数：13
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