Time-restricted feeding regulates lipid metabolism under metabolic challenges

Dysregulation of lipid metabolism is a commonly observed feature associated with metabolic syndrome and leads to the development of negative health outcomes such as obesity, diabetes mellitus, non-alcoholic fatty liver disease, or atherosclerosis. Time-restricted feeding/eating (TRF/TRE), an emerging dietary intervention, has been shown to promote pleiotropic health benefits including the alteration of diurnal expression of genes associated with lipid metabolism, as well as levels of lipid species. Although TRF likely induces a response in multiple organs leading to the modulation of lipid metabolism, a majority of the studies related to TRF effects on lipids have focused only on individual tissues, and furthermore there is a lack of insight into potential underlying mechanisms. In this review, we summarize the current insights regarding TRF effects on lipid metabolism and the potential mechanisms in adipose tissue, liver, skeletal muscle, and heart, and conclude by outlining possible avenues for future exploration. TRF modulates lipid metabolism (fatty acid synthesis and oxidation) in multi-organ and tissue-specific manners. TRF synchronizes expression rhythms of functionally related genes and temporally compartmentalizes the anabolic and catabolic processes to maintain lipid metabolic homeostasis in various tissues, based on their nutrient availability, energy need, and metabolic function.image