Tumor PD-L1 expression and molecular profiling are not associated with immune checkpoint inhibitor-induced thyroid dysfunction in advanced NSCLC patients
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作者:
Horesh, Adi
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机构:
Hebrew Univ Jerusalem, Fac Med, Jerusalem, IsraelHebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Horesh, Adi
[1
]
Pollack, Rena
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机构:
Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Hadassah Hebrew Univ, Med Ctr, Dept Endocrinol & Metab, Jerusalem, IsraelHebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Pollack, Rena
[1
,2
]
Nechushtan, Hovav
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机构:
Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Hadassah Hebrew Univ, Med Ctr, Dept Oncol, Jerusalem, IsraelHebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Nechushtan, Hovav
[1
,3
]
Dresner-Pollak, Rivka
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机构:
Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Hadassah Hebrew Univ, Med Ctr, Dept Endocrinol & Metab, Jerusalem, IsraelHebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Dresner-Pollak, Rivka
[1
,2
]
Neuman, Tzahi
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机构:
Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Hadassah Hebrew Univ, Med Ctr, Dept Pathol, Jerusalem, IsraelHebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
Neuman, Tzahi
[1
,4
]
机构:
[1] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel
[2] Hadassah Hebrew Univ, Med Ctr, Dept Endocrinol & Metab, Jerusalem, Israel
[3] Hadassah Hebrew Univ, Med Ctr, Dept Oncol, Jerusalem, Israel
[4] Hadassah Hebrew Univ, Med Ctr, Dept Pathol, Jerusalem, Israel
Background: Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC), however are frequently associated with thyroid immune-related adverse events (IRAEs). We investigated the association between patient characteristics, tumor PD-L1 expression and molecular profile with the development of thyroid IRAEs in NSCLC patients.Methods: Single center, retrospective study including 107 NSCLC patients treated with PD-1/PD-L1 inhibitors from April 2016 to July 2020. All patients were euthyroid at baseline with at least two TSH measurements post-treatment initiation. The primary outcome was the difference in tumor PD-L1 expression in patients who developed any thyroid IRAEs versus those who remained euthyroid. Additional outcomes included development of overt thyroid dysfunction, the association of specific molecular alterations with thyroid IRAEs, and onset of thyroid IRAEs as a function of tumor PD-L1 expression.Results: Overall, 37 (34.6%) patients developed any thyroid dysfunction and 18 (16.8%) developed overt thyroid dysfunction. Tumor PD-L1 staining intensity was not associated with thyroid IRAEs. TP53 mutation was less likely to be associated with any thyroid dysfunction (p < 0.05) and no association was found between EGFR, ROS, ALK or KRAS mutations. There was no association between PD-L1 expression and time to develop thyroid IRAEs.Conclusion: PD-L1 expression is not associated with the development of thyroid dysfunction in advanced NSCLC patients treated with ICIs, suggesting that thyroid IRAEs are unrelated to tumor PD-L1 expression.
机构:
Hadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Hebrew Univ Jerusalem, Fac Med, Jerusalem, IsraelHadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Pollack, Rena
Ashash, Amit
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Hebrew Univ Jerusalem, Fac Med, Jerusalem, IsraelHadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Ashash, Amit
Cahn, Avivit
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h-index: 0
机构:
Hadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Hebrew Univ Jerusalem, Fac Med, Jerusalem, IsraelHadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Cahn, Avivit
Rottenberg, Yakir
论文数: 0引用数: 0
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机构:
Hadassah Med Ctr, Sharett Inst, Dept Oncol, Jerusalem, IsraelHadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Rottenberg, Yakir
Stern, Hagay
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机构:
Hebrew Univ Jerusalem, Fac Med, Jerusalem, IsraelHadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Stern, Hagay
Dresner-Pollak, Rivka
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机构:
Hadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
Hebrew Univ Jerusalem, Fac Med, Jerusalem, IsraelHadassah Med Ctr, Dept Endocrinol & Metab, POB 12000, IL-91120 Jerusalem, Israel
机构:
Univ Virginia, Sch Med, Charlottesville, VA 22908 USAUniv Virginia, Sch Med, Charlottesville, VA 22908 USA
Moore, M.
Hall, R.
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机构:
Univ Virginia, Div Hematol Oncol, Charlottesville, VA USAUniv Virginia, Sch Med, Charlottesville, VA 22908 USA
Hall, R.
Mcloughlin, E.
论文数: 0引用数: 0
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机构:
Univ Virginia, Div Hematol Oncol, Charlottesville, VA USAUniv Virginia, Sch Med, Charlottesville, VA 22908 USA
Mcloughlin, E.
Melson, J.
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Univ Virginia, Sch Med, Charlottesville, VA 22908 USAUniv Virginia, Sch Med, Charlottesville, VA 22908 USA
Melson, J.
Horton, B.
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h-index: 0
机构:
Univ Virginia, Sch Med, Dept Publ Hlth Sci, Div Translat Res & Appl Stat, Charlottesville, AL USAUniv Virginia, Sch Med, Charlottesville, VA 22908 USA
机构:
BCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
Melosky, B.
Chu, Q.
论文数: 0引用数: 0
h-index: 0
机构:
Cross Canc Inst, Edmonton, AB, Canada
Univ Alberta, Edmonton, AB, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
Chu, Q.
Juergens, R. A.
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机构:
McMaster Univ, Juravinski Canc Ctr, Hamilton, ON, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
Juergens, R. A.
Leighl, N.
论文数: 0引用数: 0
h-index: 0
机构:
Princess Margaret Hosp, Toronto, ON, Canada
Univ Toronto, Toronto, ON, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
Leighl, N.
Lonescu, D.
论文数: 0引用数: 0
h-index: 0
机构:
BCCA, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
Lonescu, D.
Tsao, M. -S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
Tsao, M. -S.
McLeod, D.
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h-index: 0
机构:
Kaleidoscope Strateg Inc, Toronto, ON, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada
McLeod, D.
Hirsh, V.
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机构:
Royal Victoria Hosp, Montreal Gen Hosp, Montreal, PQ, Canada
McGill Univ, Montreal, PQ, CanadaBCCA Vancouver Ctr, Med Oncol, 600 West 10th Ave, Vancouver, BC V5Z 4E6, Canada