Balancing lysosome abundance in health and disease

被引：19
|
作者：
Mutvei, Anders P. P. [1 ,2 ]
Nagiec, Michal J. J. [3 ,4 ]
Blenis, John [3 ,4 ]
机构：
[1] Karolinska Inst, Dept Lab Med, Div Pathol, Huddinge, Sweden
[2] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden
[3] Weill Cornell Med Coll, Meyer Canc Ctr, New York, NY 10065 USA
[4] Weill Cornell Med Coll, Dept Pharmacol, New York, NY 10065 USA
来源：
NATURE CELL BIOLOGY | 2023年 / 25卷 / 09期
基金：
瑞典研究理事会; 美国国家卫生研究院;
关键词：
TRANSCRIPTION FACTOR; DEPENDENT REGULATION; AUTOPHAGY MAINTAINS; DAMAGED LYSOSOMES; TFEB; BIOGENESIS; MTOR; FUSION; INHIBITION; MECHANISM;
D O I：
10.1038/s41556-023-01197-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes. The mechanisms controlling lysosome abundance in cells and how changes in lysosome pool size impact physiological and pathophysiological processes are discussed.
引用
收藏
页码：1254 / 1264
页数：11
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