What Causes Seizures in Neurocysticercosis?

被引：7
|
作者：
Steyn, Teresa Julieta Simoes [1 ,2 ]
Awala, Amalia Naita [1 ,2 ]
de Lange, Anja [1 ,2 ]
Raimondo, Joseph Valentino [1 ,2 ,3 ]
机构：
[1] Univ Cape Town, Neurosci Inst, Div Cell Biol, Dept Human Biol, Western Cape, South Africa
[2] Univ Cape Town, Inst Infect Dis & Mol Med, Fac Hlth Sci, Western Cape, South Africa
[3] Univ Cape Town, Fac Hlth Sci, Anat Bldg, ZA-7935 Western Cape, South Africa
来源：
EPILEPSY CURRENTS | 2023年 / 23卷 / 02期
基金：
英国惠康基金;
关键词：
cestode; inflammation; neurocysticercosis; seizures; Taenia solium; BLOOD-BRAIN-BARRIER; TAENIA-SOLIUM CYSTICERCOSIS; PIG FARMING COMMUNITY; CALCIFIED NEUROCYSTICERCOSIS; ANTIPARASITIC TREATMENT; SLICE CULTURES; EPILEPSY; ASSOCIATION; INFECTION; LESIONS;
D O I：
10.1177/15357597221137418
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Neurocysticercosis (NCC) is the most prevalent parasitic infection of the central nervous system. It is caused by the presence of larvae of the cestode Taenia solium in the brain. The most common symptom of NCC is seizures, and it is widely considered the world's leading cause of preventable epilepsy. Despite the prevalence and impact of NCC, a thorough, mechanistic understanding of seizure generation is still lacking. In this review, we address the question "What causes seizures in NCC?" by summarizing and discussing the major theories that seek to explain the seizurogenic and epileptogenic processes in this disorder. In addition, we highlight the potential for recent advances in disease modeling to help accelerate progress in this area.
引用
收藏
页码：105 / 112
页数：8
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